中草药丹参刺五加复方制剂协同配伍对动脉粥样硬化性心脏病大鼠的药效作用研究

o investigate the mechanism of suppressive effect of Chinese medicine on Coronary Atherosclerotic Heart Disease (IHD) by observing the effect of Salvia miltiorrhiza injection coordinated with Acanthopanax senticosus injection（MSAI）on the acute myocardial ischemia rat. The optimal formula of MSAI was ascertained using design by uniform distribution. From pharmacodynamics, the rat was applied with isolated heart perfusion method, for measuring Coronary Artery Fluence . Further, Coronary Artery in rat was received physic liquor by intravenous injection using constant flow pump to determine left ventricular systolic pressure (LVSP) , left ventricular maximum pressure variation rate（LVMPVR）and left ventricular end-diastolic pressure(LVEDP). The MSAI was found that could significantly increase CF of the isolated heart of the rats(P<0.01)，compared with SI and AI control group, respectively ; in addition，the effect of Formula (Ⅲ)（syringoside : protocatechuic aldehyde = 1:1.25）is the optimization. The results of hemodynamic effect of acute myocardial ischemia in 15min rat treated with MSAI demonstrated that MSAI could remarkably raise LVSP, LVMPVR（±dp/dtmax）and lower LVEDP. Additionally, the effect on resisting acute-myocardial-ischemia of MSAI group was better than that of SI group and AI group(P<0.01). The mechanism of suppressive effect of MSAI on IHD of may be realized by increasing CF, elevating LVSP, LVMPVR（±dp/dtmax），and lowering LVEDP.