Cognitive Benefits of Exercise Interventions: An fMRI Activation Likelihood Estimation Meta-Analysis
Cognitive Benefits of Exercise Interventions: An fMRI Activation Likelihood Estimation Meta-Analysis
Abstract Despite a growing number of functional MRI studies reporting exercise-induced changes during cognitive processing, a systematic determination of the underlying neurobiological pathways is currently lacking. To this end, our neuroimaging meta-analysis included 20 studies and investigated the influence of exercise on cognition-related functional brain activation. The overall meta-analysis encompassing all experiments revealed exercise-induced changes in the left parietal lobe during cognitive processing. Subgroup analysis further revealed that in the younger-age group (<35 years old) exercise induced more widespread changes in the right hemisphere whereas in the older-age group (≥35 years old) exercise-induced changes were restricted to the left parietal lobe. Furthermore, subgroup analysis for exercise intervention duration, showed that shorter exercise interventions induced changes in regions connected with frontoparietal and default mode networks whereas regions exhibiting effects of longer interventions connected with frontoparietal and dorsal attention networks. Our findings suggest that physical exercise training leads to changes in functional activation patterns primarily located in precuneus and associated with frontoparietal, dorsal attention and default mode networks. Furthermore, exercise-induced changes in functional brain activation varied as a function of age and exercise intervention duration.
Herold Fabian、Perrey Stephane、Kramer Arthur F.、Zhang Yanjie、Yu Qian、M¨1ller Notger G.、KluGah-Brown Ben、Zou Liye、Veronese Nicola、Becker Benjamin
Research Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE)EuroMov, University of MontpellierCenter for Cognitive and Brain Health, Department of Psychology, Northeastern University||Beckman Institute, University of Illinois at Urbana-ChampaignExercise & Mental Health Laboratory, School of Psychology, Shenzhen University||Health and Exercise Science Laboratory, Institute of Sports Science, Seoul National UniversityExercise & Mental Health Laboratory, School of Psychology, Shenzhen UniversityResearch Group Neuroprotection, German Center for Neurodegenerative Diseases (DZNE)The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of ChinaExercise & Mental Health Laboratory, School of Psychology, Shenzhen UniversityPrimary Care DepartmentThe Clinical Hospital of Chengdu Brain Science Institute, MOE Key Laboratory for Neuroinformation, University of Electronic Science and Technology of China
医学研究方法神经病学、精神病学基础医学
Exercisecognitionbrain healthnetwork
Herold Fabian,Perrey Stephane,Kramer Arthur F.,Zhang Yanjie,Yu Qian,M¨1ller Notger G.,KluGah-Brown Ben,Zou Liye,Veronese Nicola,Becker Benjamin.Cognitive Benefits of Exercise Interventions: An fMRI Activation Likelihood Estimation Meta-Analysis[EB/OL].(2025-03-28)[2025-05-05].https://www.biorxiv.org/content/10.1101/2020.07.04.187401.点此复制
评论