茶碱-烟酰胺共晶热力学研究

In this paper, the cocrystal researchis an exciting scientific subject and is one of the most important compositions for the pharmacy design, pharmacy exploitation and pharmacy production. In this thesis, the theophylline (TP) - nicotinamide (NCT) cocrystal was used as an example for studying the thermodynamic analysis as the following. The dependence of the cocrystal solubility on the concentration of cocrystal components in solution were measured and explained by a cocrystal solubility product. According to solubility product, the influence of temperature on the cocrystal dissolubility was explained from the intermolecular interaction. In order to investigate how the cocrystals crystallized at different temperature, the ternary phase diagrams for the system of theophylline-nicotinamide-ethanol at different temperature were constructed and the variation with temperature was discussed. The ternary phase diagrams help us understand how the cocrystal was crystallized from the solution and provides the theoretical basis for crystallization process.