The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI
The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI
The translation of AI-generated brain metastases (BM) segmentation into clinical practice relies heavily on diverse, high-quality annotated medical imaging datasets. The BraTS-METS 2023 challenge has gained momentum for testing and benchmarking algorithms using rigorously annotated internationally compiled real-world datasets. This study presents the results of the segmentation challenge and characterizes the challenging cases that impacted the performance of the winning algorithms. Untreated brain metastases on standard anatomic MRI sequences (T1, T2, FLAIR, T1PG) from eight contributed international datasets were annotated in stepwise method: published UNET algorithms, student, neuroradiologist, final approver neuroradiologist. Segmentations were ranked based on lesion-wise Dice and Hausdorff distance (HD95) scores. False positives (FP) and false negatives (FN) were rigorously penalized, receiving a score of 0 for Dice and a fixed penalty of 374 for HD95. Eight datasets comprising 1303 studies were annotated, with 402 studies (3076 lesions) released on Synapse as publicly available datasets to challenge competitors. Additionally, 31 studies (139 lesions) were held out for validation, and 59 studies (218 lesions) were used for testing. Segmentation accuracy was measured as rank across subjects, with the winning team achieving a LesionWise mean score of 7.9. Common errors among the leading teams included false negatives for small lesions and misregistration of masks in space.The BraTS-METS 2023 challenge successfully curated well-annotated, diverse datasets and identified common errors, facilitating the translation of BM segmentation across varied clinical environments and providing personalized volumetric reports to patients undergoing BM treatment.
David Weiss、Alexandra Frick、Sarah Maria Jacobs、R. Ian Gray、Katherine E. Link、Khaled Bousabarah、Hasan Kassem、Eric D. Schwartz、Tasneem Elakhdar、Petra Cimflova、Uresh Patel、Francesca Pappafava、Sanjay Aneja、Katharina Kersting、Mohamed Badawy、Rachit Saluja、Philipp Vollmuth、Mana Moassefi、Ajay Malhotra、Scott Raymond、Fabricio Feltrin、Sadeq Sabouhi、Rui Duarte Armindo、Maria Correia de Verdier、Felix Corr、Jewels Valerie、Martin Bendszus、Athanasios Gkampenis、Theodora Soumala、Derek R. Johnson、Farouk Dako、Ayman Nada、Gianluca Brugnara、Keyvan Farahani、Nima Broomand Lomer、Ioannis Koukoulithras、Alexis Crawley、Talissa Altes、James Eddy、Manpreet Kaur、Harrison Moy、Anousheh Sayah、Sedat G. Kandemirli、Saurabh Rohatgi、Luca Pasquini、Chase Krumpelman、Francesco Dellepiane、MingDe Lin、Jim Chen、Edvin Isufi、Ozkan Ozsarlak、Jaime Gass、Oleg Teytelboym、Abdul Rahman Tarabishy、Amit Mahajan、Jaeyoung Cho、Vaibhav Gulati、Mark S. Shiroishi、Ruxandra-Catrinel Maria-Zamfirescu、Vahe M. Zohrabian、Scott Floyd、Eric Rawie、Juan E. Small、Mahsa Taherzadeh、Benedikt Wiestler、Laurent Letourneau-Guillon、Benjamin Turner、Ujjwal Baid、Spyridon Bakas、Ivan Ezhov、Kholod Ashraf、Pamela LaMontagne、Lillian Lai、Luciano Farage、Zachary Reitman、Walter Wiggins、Yalda Nikanpour、Veronica Chiang、Pokhraj P. Suthar、Nader Ashraf、Sofia Kollia、Nastaran Khalili、Jeffrey D. Rudie、Zeke Meier、Sarthak Pati、Daniel Warren、Mark Krycia、Ahmed W. Moawad、Koen Van Leemput、Benjamin Yin Ming Kwan、Kuang-chun Jim Hsieh、Abdullah Mohamed Aly Nouh、Xinyang Liu、Muhammad Ammar Haider、Fatima Hierro、Yuri S. Velichko、Zoe Shaked、Bjoern H Menze、Mark McArthur、Mostafa Alnoury、Zhifan Jiang、Udunna Anazodo、Moamen M. Asla、Laura Kida、Amy Fong、Aynur Azizova、Hesham Elhalawani、Esther A. Nimchinsky、Abdullah Okar、Islam H. Shawali、Arman Avesta、Yasaman Sharifi、Micah Sheller、Nikolay Yordanov、Klara Willms、Niklas Tillmans、Ayda Youssef、Anthony Kam、Nourel hoda Tahon、Ichiro Ikuta、Maruf Adewole、Jake Albrecht、George K. Vilanilam、Leon Jekel、Gabriel Cassinelli Pedersen、Justin Cramer、Cristina Besada、Anahita Fathi Kazerooni、Wolfgang Holler、Jason Druzgal、Atin Saha、Chunhao Wang、Philipp Lohmann、Aristeidis Sotiras、Brent D. Weinberg、Lisa Deptula、Gian Marco Conte、Gerard Thompson、Robert Shih、Fikadu Worede、Ahmed Abouelatta、Evan Calabrese、Robert Young、Samantha Petrucci、Timothy Bergquist、Olivia McDonnell、Jan Bukatz、David Joyner、Irada Pfluger、Maire McHugh、Sarah Merkaj、Verena Chung、Russell Takeshi Shinohara、Divya Ramakrishnan、Anu Bansal、Sanaria Al-Rubaiey、Malte Westerhoff、Sara Yousry、Martha Foltyn-Dumitru、Hongwei Bran Li、Mohamed Ghonim、Melanie Maria Theresa Bruseler、Fatima Memon、Manoj Tanwar、Devon Godfrey、Borna Roohani、Laura M. Sanchez-Garcia、Umber Shafique、Alejandro Aristizabal、Elka Miller、Marc von Reppert、Michael Iv、Raisa Amiruddin、E. Brooke Schrickel、Bojan Petrovic、Sebastiano Vacca、Marius George Linguraru、Satrajit Chakrabarty、Syed Raza Naqvi、Markand D. Patel、Yohana Sarahi Mateo-Camacho、Andreas Rauschecker、Frederik Barkhof、Sammy Chu、Samah Mostafa Morsi、Khanak K. Nandolia、Christie M. Lincoln、Yaseen Dhemesh、Alexandru Dusoi、Jeroen Bisschop、Marcela Marsiglia、Alexander Munteanu、Klara Osenberg、Gloria J. Guzman Perez-Carillo、Gagandeep Singh、Alexandros Karargyris、Anastasia Janas、Jan Lost、Mate E. Maros、Mohanad Ghonim、Marie Piraud、Aya Mansour、Juan Eugenio Iglesias、Nicolo Gennaro、Elaine Johanson、Alida A. Postma、Aly H. Abayazeed、Matthew L. White、Satya Narayana Patro、Rasmus Holmboe Dahl、Syed Muhammad Anwar、Javier Villanueva-Meyer、Neil U. Lall、Ryan Maresca、Dominic LaBella、Tiffany Y. So、Steve H. Fung、Shahriar Faghani、Jonathan Thacker、Amirreza Manteghinejad、Xiao Li、Pascal Fehringer、Daniel S. Marcus、Kiril Krantchev、Mariam Aboian、Nazanin Maleki、Victor M. Perez-Garcia、Nico Sollmann、Florian Kofler、Wondwossen Lerebo、Lei Wu、Fanny Moron
肿瘤学神经病学、精神病学医学研究方法
David Weiss,Alexandra Frick,Sarah Maria Jacobs,R. Ian Gray,Katherine E. Link,Khaled Bousabarah,Hasan Kassem,Eric D. Schwartz,Tasneem Elakhdar,Petra Cimflova,Uresh Patel,Francesca Pappafava,Sanjay Aneja,Katharina Kersting,Mohamed Badawy,Rachit Saluja,Philipp Vollmuth,Mana Moassefi,Ajay Malhotra,Scott Raymond,Fabricio Feltrin,Sadeq Sabouhi,Rui Duarte Armindo,Maria Correia de Verdier,Felix Corr,Jewels Valerie,Martin Bendszus,Athanasios Gkampenis,Theodora Soumala,Derek R. Johnson,Farouk Dako,Ayman Nada,Gianluca Brugnara,Keyvan Farahani,Nima Broomand Lomer,Ioannis Koukoulithras,Alexis Crawley,Talissa Altes,James Eddy,Manpreet Kaur,Harrison Moy,Anousheh Sayah,Sedat G. Kandemirli,Saurabh Rohatgi,Luca Pasquini,Chase Krumpelman,Francesco Dellepiane,MingDe Lin,Jim Chen,Edvin Isufi,Ozkan Ozsarlak,Jaime Gass,Oleg Teytelboym,Abdul Rahman Tarabishy,Amit Mahajan,Jaeyoung Cho,Vaibhav Gulati,Mark S. Shiroishi,Ruxandra-Catrinel Maria-Zamfirescu,Vahe M. Zohrabian,Scott Floyd,Eric Rawie,Juan E. Small,Mahsa Taherzadeh,Benedikt Wiestler,Laurent Letourneau-Guillon,Benjamin Turner,Ujjwal Baid,Spyridon Bakas,Ivan Ezhov,Kholod Ashraf,Pamela LaMontagne,Lillian Lai,Luciano Farage,Zachary Reitman,Walter Wiggins,Yalda Nikanpour,Veronica Chiang,Pokhraj P. Suthar,Nader Ashraf,Sofia Kollia,Nastaran Khalili,Jeffrey D. Rudie,Zeke Meier,Sarthak Pati,Daniel Warren,Mark Krycia,Ahmed W. Moawad,Koen Van Leemput,Benjamin Yin Ming Kwan,Kuang-chun Jim Hsieh,Abdullah Mohamed Aly Nouh,Xinyang Liu,Muhammad Ammar Haider,Fatima Hierro,Yuri S. Velichko,Zoe Shaked,Bjoern H Menze,Mark McArthur,Mostafa Alnoury,Zhifan Jiang,Udunna Anazodo,Moamen M. Asla,Laura Kida,Amy Fong,Aynur Azizova,Hesham Elhalawani,Esther A. Nimchinsky,Abdullah Okar,Islam H. Shawali,Arman Avesta,Yasaman Sharifi,Micah Sheller,Nikolay Yordanov,Klara Willms,Niklas Tillmans,Ayda Youssef,Anthony Kam,Nourel hoda Tahon,Ichiro Ikuta,Maruf Adewole,Jake Albrecht,George K. Vilanilam,Leon Jekel,Gabriel Cassinelli Pedersen,Justin Cramer,Cristina Besada,Anahita Fathi Kazerooni,Wolfgang Holler,Jason Druzgal,Atin Saha,Chunhao Wang,Philipp Lohmann,Aristeidis Sotiras,Brent D. Weinberg,Lisa Deptula,Gian Marco Conte,Gerard Thompson,Robert Shih,Fikadu Worede,Ahmed Abouelatta,Evan Calabrese,Robert Young,Samantha Petrucci,Timothy Bergquist,Olivia McDonnell,Jan Bukatz,David Joyner,Irada Pfluger,Maire McHugh,Sarah Merkaj,Verena Chung,Russell Takeshi Shinohara,Divya Ramakrishnan,Anu Bansal,Sanaria Al-Rubaiey,Malte Westerhoff,Sara Yousry,Martha Foltyn-Dumitru,Hongwei Bran Li,Mohamed Ghonim,Melanie Maria Theresa Bruseler,Fatima Memon,Manoj Tanwar,Devon Godfrey,Borna Roohani,Laura M. Sanchez-Garcia,Umber Shafique,Alejandro Aristizabal,Elka Miller,Marc von Reppert,Michael Iv,Raisa Amiruddin,E. Brooke Schrickel,Bojan Petrovic,Sebastiano Vacca,Marius George Linguraru,Satrajit Chakrabarty,Syed Raza Naqvi,Markand D. Patel,Yohana Sarahi Mateo-Camacho,Andreas Rauschecker,Frederik Barkhof,Sammy Chu,Samah Mostafa Morsi,Khanak K. Nandolia,Christie M. Lincoln,Yaseen Dhemesh,Alexandru Dusoi,Jeroen Bisschop,Marcela Marsiglia,Alexander Munteanu,Klara Osenberg,Gloria J. Guzman Perez-Carillo,Gagandeep Singh,Alexandros Karargyris,Anastasia Janas,Jan Lost,Mate E. Maros,Mohanad Ghonim,Marie Piraud,Aya Mansour,Juan Eugenio Iglesias,Nicolo Gennaro,Elaine Johanson,Alida A. Postma,Aly H. Abayazeed,Matthew L. White,Satya Narayana Patro,Rasmus Holmboe Dahl,Syed Muhammad Anwar,Javier Villanueva-Meyer,Neil U. Lall,Ryan Maresca,Dominic LaBella,Tiffany Y. So,Steve H. Fung,Shahriar Faghani,Jonathan Thacker,Amirreza Manteghinejad,Xiao Li,Pascal Fehringer,Daniel S. Marcus,Kiril Krantchev,Mariam Aboian,Nazanin Maleki,Victor M. Perez-Garcia,Nico Sollmann,Florian Kofler,Wondwossen Lerebo,Lei Wu,Fanny Moron.The Brain Tumor Segmentation (BraTS-METS) Challenge 2023: Brain Metastasis Segmentation on Pre-treatment MRI[EB/OL].(2023-06-01)[2025-05-28].https://arxiv.org/abs/2306.00838.点此复制
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