利用CFD软件对毛细管电泳芯片进样口形状的优化设计

Based on the theory of electroosmosis flow, the different structure model of microchip electrophoresis were set up, and the fluid flow situation in the microchannel were simulated with the CFD software at the different design parameter and the voltage combination. The final simulation results indicate that the shape of sample injection on the Microchip Electrophoresis is the rectangle, the width of the microchannel is the 20冚m, the electric field strength of the sample injection and separation is between 200 ~ 250 v/cm. Also a kind of spiral microchannel mode had been optimized with the better separation efference in the all microchip electrophoresis.