A framework for evaluating correspondence between brain images using anatomical fiducials
A framework for evaluating correspondence between brain images using anatomical fiducials
Abstract Accurate spatial correspondence between template and subject images is a crucial step in neuroimaging studies and clinical applications like stereotactic neurosurgery. In the absence of a robust quantitative approach, we sought to propose and validate a set of point landmarks, anatomical fiducials (AFIDs), that could be quickly, accurately, and reliably placed on magnetic resonance images of the human brain. Using several publicly available brain templates and individual participant datasets, novice users could be trained to place a set of 32 AFIDs with millimetric accuracy. Furthermore, the utility of the AFIDs protocol is demonstrated for evaluating subject-to-template and template-to-template registration. Specifically, we found that commonly used voxel overlap metrics were relatively insensitive to focal misregistrations compared to AFID point-based measures. Our entire protocol and study framework leverages open resources and tools, and has been developed with full transparency in mind so that others may freely use, adopt, and modify. This protocol holds value for a broad number of applications including alignment of brain images and teaching neuroanatomy.
Lau Jonathan C.、Kuehn Tristan、Park Patrick J.、Stanley Olivia W.、Kai Jason、Gupta Geetika、Peters Terry M.、Parrent Andrew G.、Ferko Kayla、Khan Ali R.、Demarco John
Department of Clinical Neurological Sciences, Division of Neurosurgery, Western University||Imaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||School of Biomedical Engineering, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||School of Biomedical Engineering, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||Department of Medical Biophysics, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||Department of Medical Biophysics, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||School of Biomedical Engineering, Western University||Brain and Mind Institute, Western University||Department of Medical Biophysics, Western UniversityDepartment of Clinical Neurological Sciences, Division of Neurosurgery, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||Brain and Mind Institute, Western University||Graduate Program in Neuroscience, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University||School of Biomedical Engineering, Western University||Brain and Mind Institute, Western University||Graduate Program in Neuroscience, Western University||Department of Medical Biophysics, Western UniversityImaging Research Laboratories, Robarts Research Institute, Western University||Centre for Functional and Metabolic Mapping, Robarts Research Institute, Western University
神经病学、精神病学基础医学生物科学研究方法、生物科学研究技术
brainatlasaccuracytemplateneuroanatomynonlinear registrationpallidumstriatumthalamusquality controldeep brain stimulationeducation
Lau Jonathan C.,Kuehn Tristan,Park Patrick J.,Stanley Olivia W.,Kai Jason,Gupta Geetika,Peters Terry M.,Parrent Andrew G.,Ferko Kayla,Khan Ali R.,Demarco John.A framework for evaluating correspondence between brain images using anatomical fiducials[EB/OL].(2025-03-28)[2025-04-24].https://www.biorxiv.org/content/10.1101/460675.点此复制
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