大型真菌鸟巢烷型二萜化合物
Cyathane Diterpenoids of Macrofungi
鸟巢烷型二萜是高等真菌中独特的次生代谢产物产物，具有罕见的特征性的5/6/7三环骨架。这类型化合物生物活性广泛，据报道具有抗菌活性（尤其对耐甲氧西林金黄色葡萄球菌具有抑制作用）、抗炎和抗增殖性、激动κ阿片受体活性和抑制破骨细胞的形成的活性。在众多生物活性中引起广泛兴趣的是依赖神经生长因子(NGF)的神经营养活性，因此这类天然产物是具有神经营养活性的化合物，在治疗神经退行性疾病中具有潜在价值。本综述引用了96篇文献，对鸟巢烷型二萜类化合物分离纯化、结构鉴定、活性及初步的机理探讨和构效关系研究进行了详细的介绍。
生物化学药学基础医学
药物化学鸟巢烷型二萜大型真菌天然产物生物活性
尹霞,曹琛彧,高锦明.大型真菌鸟巢烷型二萜化合物[EB/OL].(2015-09-07)[2025-09-22].http://www.paper.edu.cn/releasepaper/content/201509-58.点此复制
Cyathane diterpenoids, occurring exclusively in higher mushrooms, represent an important class of secondary metabolites, possessing a characteristic 5/6/7 tricyclic carbon scaffold. These compounds show a diverse range of biological activities, such as antimicrobial, anti-MRSA, agonistic toward the kappa-opioid receptor, anti-inflammatory, anti-proliferative and NGF-like properties. This review, citing 96 references, summarises their chemistry and bioactivities of cyathane diterpenoids isolated from higher mushrooms in the last four decades, to illustrate the chemo-diversity and biological significance of these diterpenoids.
Medicinal chemistrycyathane diterpenesmushroomsnatural productsbioactivity
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