Microstructural dynamics of motor learning and sleep-dependent consolidation: a diffusion imaging study
Legouhy Antoine 1Guerreri Michele 1Villemonteix Thomas 2Peigneux Philippe 3Stee Whitney 3Zhang Hui1
作者信息
- 1. Department of Computer Science & Centre for Medical Image Computing, University College London (UCL)
- 2. UR2NF-Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN ¨C Centre for Research in Cognition and Neurosciences and UNI - ULB Neuroscience Institute, Universit¨| Libre de Bruxelles (ULB)||Laboratoire Psychopathologie et Processus de Changement, Paris-Lumi¨¨res University
- 3. UR2NF-Neuropsychology and Functional Neuroimaging Research Unit affiliated at CRCN ¨C Centre for Research in Cognition and Neurosciences and UNI - ULB Neuroscience Institute, Universit¨| Libre de Bruxelles (ULB)||GIGA - Cyclotron Research Centre - In Vivo Imaging, University of Li¨¨ge (ULi¨¨ge)
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Abstract
Summary
Diffusion-weighted magnetic resonance imaging (DWI) allows the observation of (micro)structural brain remodelling in cortical and subcortical regions after time-limited motor learning. Post-learning sleep consolidation should lead to long-term microstructural brain changes, but concrete evidence remains limited. Here, we used both conventional diffusion tensor imaging (DTI) and Neurite Orientation Dispersion & Density Imaging (NODDI), that estimates dendritic and axonal complexity in white and grey matter, to investigate the microstructural brain mechanisms underlying time- and sleep-dependent motor memory consolidation. Sixty-one young healthy adults underwent 2 DWI sessions, with sequential motor training in between, on day 1 followed by the experimental night of total sleep deprivation or regular sleep. After 3 recovery nights at home, they underwent 2 further DWI sessions separated by a motor retraining session. Sequential motor learning resulted in immediate modifications in structural parameters in occipitoparietal and temporal regions, as well as in subcortical regions of interest. Similar changes were observed following relearning but at a smaller magnitude. Regarding delayed consolidation effects, learning-related changes only partially persisted 3 days after initial learning, and no post-learning sleep effect was detected. Our results show rapid motor learning-related remodelling, reflecting temporary processes in learning-related neuronal brain plasticity. Post-learning sleep-related cellular changes remain to be evidenced, possibly using more sophisticated brain imaging measures and spanning more extended timescales to allow the expression of structural changes.Key words
diffusion imaging/NODDI/DTI/sleep/motor memory/sequential motor learning/structural plasticity/microstructure引用本文复制引用
Legouhy Antoine,Guerreri Michele,Villemonteix Thomas,Peigneux Philippe,Stee Whitney,Zhang Hui.Microstructural dynamics of motor learning and sleep-dependent consolidation: a diffusion imaging study[EB/OL].(2025-03-28)[2026-04-03].https://www.biorxiv.org/content/10.1101/2023.05.30.542891.学科分类
基础医学/神经病学、精神病学
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