白血病干细胞表面分子标志物及分化抗原高表达与难治性急性白血病
he High Expression of Surface Molecular Markers and Differentiation Antigens of Leukaemia Stem Cells in Refractory Acute Leukemia
白血病是一类起源于造血干细胞的恶性克隆性疾病，自Lapidot等首次报道了具有CD34+/CD38-表型的LSC以来，越来越多的研究表明，LSC在维持白血病的存在、抵御细胞毒药物的杀伤、白血病复发、难治以及白血病多药耐药等方面起着重要作用。其中，白血病复发及其难治与LSC表面分子标志物及分化抗原高表达密切相关。因此，以LSC特异性表面抗原或分子标志物为靶点，寻找和发现治疗白血病的生物靶向药物已经成为可能治愈白血病研究的重点。
cute leukemia is one of the malignant cloning diseases derived from hematopoietic stem cell, an increasing number of researches indicate that LSC plays a key role in leukemia relapse and refractory, reducing the effect of cytotoxic drugs and the multidrug resistance in Leukemia since Lapidot discovered the CD34+/CD38- of LSC for the first time. The relapse and refractory of leukemia are closely related to the high expression of differentiation antigens and the surface molecular markers of LSC. Consequently, the biological target drug, which targets specific surface antigens or molecular markers of LSC, has become the new emphasis in the research of leukemia.
王婧、王荣华、褚雨霆、陈信义
基础医学肿瘤学分子生物学
白血病干细胞分子标志物分化抗原难治性急性白血病
Leukemia stem cellMolecular markersDifferentiation antigensRefractory acute leukemia
王婧,王荣华,褚雨霆,陈信义.白血病干细胞表面分子标志物及分化抗原高表达与难治性急性白血病[EB/OL].(2012-01-04)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201201-13.点此复制
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