基于网络药理学的黄柏治疗溃疡性结肠炎机制探讨

Objective：To explore the mechanism of Phellodendri Chinensis Cortex in treatment of ulcerative colitis（UC）through network pharmacology method. Methods：The active ingredients and targets of Phellodendri Chinensis Cortex were obtained through the BATMAN-TCM database, UC-related targets were searched by GeneCards database. The targets of Phellodendri Chinensis Cortex were corresponding to UC-related targets, the common targets and key active ingredients were screened. Cytoscape 3.8.2 software was used to construct the active ingredients-targets network, and a protein-protein interaction network was obtained by STRING database. GO function enrichment and KEGG signal pathway enrichment were analyzed by DAVID online tool. Results：A total of 26 active ingredients related to UC were obtained from Phellodendri Chinensis Cortex, and the key targets were DRD2, ESR1, NR3C1, ADRA2A and AR, which mainly involved in the Inflammatory mediator regulation of TRP channels, Sphingolipid Signaling pathways, cAMP and TNF signaling pathway by KEGG enrichment analysis. Conclusion：Phellodendri Chinensis Cortex can treat UC through a multi-ingredients, multi-targets and multi-pathways approach, which provides a new direction for future research.