K1和Ki-67在三阴性乳腺癌中的表达及其与预后的关系

Objective To analyze the expressions of Thymidine Kinase 1(TK1) and nuclear-associated antigen Ki-67(Ki-67) in triple negative breast cancer(TNBC) and their prognosis. Methods There were 120 cases collected randomly,each group was 60 cases.The expression of TK1 and Ki67 in different breast tissue were detected by IHC technique. The relations of the two expressions with patient's age, tumor size, menopausal state, histological staging, lymphatic metastasis and the prognosis of patients were analyzed. Results: The positive rate of TK1 expression in TNBC was 83.33%,and that in non-TNBC was 51.67%, the difference being significant(χ2 = 13.713, P = 0.000). The positive rate of Ki-67 expression in TNBC was 68.33%, and that in non-TNBC was 31.67%, the difference being significant(χ2 = 16.133, P = 0.000). In TNBC, the expression of TK1 was related with histological staging (P = 0.013), and that of Ki-67 was related with histological staging(P = 0.013) and lymphatic metastasis(P = 0.000). The expression of TK1 was positively related with that of Ki-67 (χ2 = 5.143; r = 0.369, P = 0.023). The results of survival analysis showed that positive expression of both TK1 and Ki-67 represent worse prognosis than that not. Conclusion: The expressions of TK1 and Ki-67 in TNBC was different from that in non-TNBC, are expected to become prognostic indicators, and thereby, provide a direction of characteristics and endocrine therapy.