朊病毒特性与致病机理研究进展
Advances in the researches on characterization and disease mechanism of prions
杨飞宇 边静静 胡鹏年 陈扶香 刁小龙 施福明 徐志良
作者信息
摘要
朊病毒病是人和动物的一种退行性脑病，主要包括羊骚痒病，疯牛病，以及人的克??雅氏综合症。其致病因子被认为是一种由正常细胞PrP蛋白经非正常折叠所形成的蛋白质
（PrPsc）。PrPsc和PrPc来自于同一基因具有相同的氨基酸序列，但在二级结构和三级结构上有很大的不同。因为PrPsc是一种不含有核酸的蛋白质感染因子，所以关于朊病毒的致病机理至今还没有完全弄清楚。但有关研究表明该病是由于PrPsc或ctmPrP在大脑中积累所致Abstract
Prion diseases is a kind of neurodegenerative disorders in both humans and animals,including scrapie in sheep,BSE in cattle and CJD in human.The pathogenic factor of these diseases is thought to be a abnormal isoform protein (PrPsc) of a normal cellular protein-PrPc. PrPsc and PrPc come from a same gene and have the identical amino acid sequence ,but there are some remarkable difference in secondary and tertiary structure.. PrPsc is a protein-only infection factor,so the mechanism of the disease is still unclear.However,studies indicate that the disease is caused by the accumulation of PrPsc or ctmPrP in the brain 关键词
朊病毒 PrPc PrPscKey words
prion PrPc PrPsc引用本文复制引用
杨飞宇,边静静,胡鹏年,陈扶香,刁小龙,施福明,徐志良.朊病毒特性与致病机理研究进展[EB/OL].(2006-06-08)[2025-12-13].http://www.paper.edu.cn/releasepaper/content/200606-123.学科分类
神经病学、精神病学/基础医学/分子生物学
评论