阿托伐他汀对自发性高血压大鼠左心室重塑的影响

Objective：To evaluate the effects of atorvastatin on left ventricular hypertrophy and activity of cardiomyocyte sarcoplasmic reticulum Ca2+-ATPase (SERCA) in spontaneously hypertensive rats (SHR). Methods：Twelve eight-week-old SHR were randomized into atorvastatin treated group (ATV group, n=6) and SHR group (n=6), and Wistar-Kyoto rats (WKY, n=6) was as normal controls. Atorvastatin was administered to ATV group for 10 weeks by gavage in mixture with distilled water 1 ml. Serum concentrations of total cholesterol and triglycerides was determined, and systolic blood pressure of caudal artery was examined before and after treatment. Heart wt./body wt. ratio (mg/g) was calculated and cardiomyocyte transverse diameter (TDM) was measured. Results：After 10 weeks, systolic blood pressure in ATV group was markedly lower than that in SHR group (P<0.01). Serum concentrations of total cholesterol and triglycerides were significantly decreased in ATV group than in SHR group (P<0.01, P<0.01). Heart wt./body wt ratio in SHR group was remarkably higher than WKY group (P<0.01, P<0.01). TDM in SHR group was remarkably higher than ATV group and WKY group (P<0.01, P<0.01), whereas no such difference was found between the latter groups (P>0.05). The activity of SERCA in left ventricle in SHR group was remarkably lower than that in WKY group (P<0.01), that was a little higher in ATV group than in SHR group(P>0.05). CONCLUSION Atorvastatin inhibites cardiac TDM and improves arterial systolic blood pressure, and there is no effect on activity of SERCA in left ventricle in SHR.