73在白血病中的表达特点和临床意义

Objective: To study expression of CD73 on bone marrow nucleated cells (BMNCs) in various leukemia subtypes and their relationship with cell differentiation. Methods: Immunocytochemistry and Wright - Giemsa staining BMNCs from 75 cases of leukemia, 11 cases of myelodysplastic syndrome, 13 and 9 cases of non-leukemic patients, as well as 9 health adults, analyzing CD73+ BMNCs proportions and their relationships in studying groups. Results: CD73+ BMNCs proportions in com-B ALL, pre-B ALL and PLL were significantly higher than B-CLL (P <0.05). CD73+ BMCs proportions in AML subtypes of M1, M2a, t (8; 21), t (15; 17), M4 and M5 were markedly higher than MDS respectively, but M6 close to MDS and lower than other AML subtypes. CD73+ BMCs Proportions in T-ALL, B-CLL, M6, MDS, non-leukemia patients and heath adults were close and all of them lower than B-ALL and other AML subtypes. Conclusion: The expression of CD73 was associated with leukemia subtype, differentiation and development. The higher differentiation of leukemia cell, the lower of CD73 expression in myeloid and B cell Lymphocytic leukemia, but T-ALL does not meet this pattern.