药物纳米结晶的固体化方法以及产品性质的影响因素

Nanocrystals play an important role in improving the oral bioavailability of poorly water soluble drugs. Owing to the simple preparation process, high drug loading and good scalability, nanocrystals were popular with many researchers and manufacturers. However, due to the large surface energy generated during the nanonization, nanocrystals are thermodynamically unstable, prone to aggregation and/or sedimentation during the storage, which may results in a poor oral bioavailability. Accordingly, to improve the stability, the solidification is needed. In this paper, we introduced the principle and characteristics of the commonly used solidification methodsfor nanocrystals, including spray drying, freeze drying, fluidized bed coating / granulation and spray freeze drying. What is more, the factors affecting the quality of the spray dried and freeze dried products are described briefly.