腰椎椎骨错缝对大鼠神经递质表达的实验研究

Objective: Research the lumbar vertebrae semi-dislocation impacted on the neurotransmitter expression of dorsal root ganglion in rat models. Methods: 120 SPF level SD male rats were randomized divided into rotary fixation group (RF group), simple fixation group (SF group) and sham-operation group (sham group). Each group was divided into 4 sub-group, including 1, 4, 8 and 12 weeks sub-groups. The external link fixation system was implanted into the L4-L6 of RF group and SF group rats. In RF group rats, The L5 spinous process was rotated to the right side. Make the L4, L6 and L5 spinous process were not in a straight line. In SF group rats, the external link fixation system was implanted simply and not rotated. The SP content of hypothalamus and dorsal root ganglion were examined in the 1 week, 4 weeks, 8 weeks and 12 weeks later after fixation. Results: The RF group and SF group rats' SP content in dorsal root ganglion was higher than sham group after1, 4 , 8 and 12 weeks fixation (P<0.05). Conclusion: The lumbar vertebrae semi-dislocation can promote the synthesis and transmission of SP in dorsal root ganglion, so as to cause or aggravate the pain.