大气污染对慢性阻塞性肺疾病住院影响的Meta-分析

o evaluate the relationship between air pollution and daily hospitalization for chronic obstructive pulmonary disease (COPD) with Meta-analysis, and the exposure-effects relationship recommended in the present paper can be applied to the health risk assessment of air pollution in cities. Methods Time-series and case-crossover on the exposure-effects relationship between short-term exposure to particulate matter with aerodynamic diameters less than 10um and 2.5μm (PM10 and PM2.5), sulfur dioxide (SO2), nitrogen dioxide (NO2), ozone (O3) and carbon monoxide (CO) and daily hospitalization for COPD were retrieved from PubMed, Medline, Chineses periodical full text database (CNKI), Wanfang database and Vip information database. Based on reviewing full text, the data were selected, evaluated and accessed. RevMan 5.0 software was used to perform the exposure-effects relationship between air pollution and COPD admission. Results A tolal of 11 studies were available for this analysis, including 1,128,241 patients. The Meta-analysis results of exposure-effects relationship between air pollution and COPD admission showed per 10ug/m3 increase in PM2.5, PM10, SO2, NO2, O3 and PM10 concentrations the relative risk estimates increased by 0.05%（95%CI：0.02%~0.13%）；0.08%（95%CI：0.03%~0.27%）；0.09%（95%CI：0.03%~0.32%） 0.24%（95%CI：0.21%~0.26%）；0.05%（95%CI：0.01%~0.17%）and per 1mg/m3 increase in CO concentrations the relative risk estimates increased by 0.18%（95%CI：0.12%~0.29%）. Conclusion We concluded that air pollution were significantly associated with COPD hospitalization.