生长追赶和早期营养干预对小于胎龄大鼠脂联素水平及胰岛素抵抗的远期影响

Objective To observe the long-term effect of catch-up growth and early nutrition on the adiponectin level and insulin resistance of SGA rats. Methods A no-catch-up growth SGA(SGA-NCU) and catch-up growth SGA models were built. All pups were fed with normal diet from the 4th to 12th weeks of age. On the other hand, various litters of 3 weeks SGA-NCU rats were randomly divided into SGA high-lipid group (SGA-HL) and SGA non-high-lipid group (SGA-NHL). The SGA-HL rats were fed with high lipid diet and the SGA-NHL with normal diet from the 4th to 24th weeks of age. At the end of the experiment, the glucose tolerance test and insulin release test were performed. The glucose, insulin and adiponectin were detected. Results ①At the age of 12th weeks, the length of SGA-CU was not significantly different, compared with the AGA rats, and the weigh and BMI of SGA-CU were significantly higher than those of SGA-NCU. the HOMA-IR of SGA-CU was higher than that of AGA and SGA-NCU. The adiponectin level was lower significantly than those of AGA and SGA-NCU. The outcomes of glucose tolerance test showed that the glucose levels of 30 and 60min were higher in SGA-CU than that in SGA-NCU and AGA groups. There was no significant difference in the insulin levels among SGA-CU, AGA and SGA-NCU groups. ②After 21-weeks nutrition diet, the weight, BMI and HOMA-IR of SGA-HL were significantly higher than those of SGA-NHL. The adiponectin level of SGA-HL was higher significantly not only than that of AGA, but also than that of SGA-NHL. The glucose tolerance test indicated that the glucose levels of 0, 30 and 60min were higher significantly in SGA-HL and SGA-NHL than those in AGA. While, there was no significant difference between SGA-HL and SGA-NHL. The insulin release test demonstrated that the insulin level of 30 min was higher significantly in SGA-HL than that in SGA-NHL. Conclusions Catch-up growth and early nutrition will have a long-tern effect on the adiponectin and insulin resistance of SGA.