雄激素的非基因组效应及其机制

ndrogen's rapid time course of action is not initially dependent on genomic mechanisms in the absence of the cellular machinery necessary for transcription/translation. Rapid actions of androgens affect the development of gonads and the physiological activities of many tissues and organs, such as the immune system, cardiovascular system and the nervous system. The physiological effect of the non-genomic stimulation in vivo remains largely unclear. In addition, non-genomic androgen effects can function independently, or in tandem, with the other genomic effects, to initiate steroid responses. The genomic and non-genomic pathways of androgen action are likely inter-linked and can act in concert to affect normal cell function. In the present paper, the non-genomic effects of androgens are reviewed, along with a discussion of the possible role non-genomic androgen actions have on animal physiology and behavior.