Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts
Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts
Abstract While Immune checkpoint inhibition (ICI) therapy shows significant efficacy in metastatic melanoma, only about 50% respond, lacking reliable predictive methods. We introduce a panel of six proteins aimed at predicting response to ICI therapy. Evaluating previously reported proteins in two untreated melanoma cohorts, we used a published predictive model (EaSIeR score) to identify potential proteins distinguishing responders and non-responders. Six proteins initially identified in the ICI cohort correlated with predicted response in the untreated cohort. Additionally, three proteins correlated with patient survival, both at the protein, and at the transcript levels, in an independent immunotherapy treated cohort. Our study identifies predictive biomarkers across three melanoma cohorts, suggesting their use in therapeutic decision-making. biorxiv;2024.05.01.592032v1/UFIG1F1ufig1
Almeida Nat¨￠lia Pinto de、Parada Indira Pla、P¨￠l Dorottya、Lengyel Anna S¨￠ra、Nogueira F¨￠bio、Szasz A. Marcell、Guedes J¨|ssica、Ujfaludi Zsuzsanna、Kim Yonghyo、Baldetorp Bo、Betancourt Lazaro、Appelqvist Roger、K¨￠rp¨￠ti Sarolta、Murillo Jimmy Rodriguez、Malm Johan、Kuras Magdalena、Sanchez Aniel、Paw?owski Krzysztof、MarkoVarga Gy?rgy、Doma Vikt¨?ria、Szeitz Beata、Kwon Ho-Jeong、Pahi Zolt¨￠n G¨￠bor、Kem¨|ny Lajos V.、Feny? David、Gil Jeovanis、Bartha Aron、Domont Gilberto、Szadai Leticia、Lakatos Alexandra、Gy?rffy Bal¨￠zs、Horvatovich Peter、J¨￠nosi ¨￠gnes Judit、N¨|meth Istv¨￠n Bal¨￠zs、Welinder Charlotte、Wieslander Elisabet、Woldmar Nicole、Pankotai Tibor
Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University||Chemistry Institute Federal, University of Rio de JaneiroSection for Clinical Chemistry, Department of Translational Medicine, Lund University, Sk?ne University Hospital Malm?HCEMM-SU Translational Dermatology Research Group||Department of Physiology, Semmelweis University||Department of Dermatology Semmelweis UniversityHCEMM-SU Translational Dermatology Research Group||Department of Physiology, Semmelweis University||Department of Dermatology Semmelweis UniversityChemistry Institute Federal, University of Rio de JaneiroDepartment of Internal Medicine and Oncology, Semmelweis UniversitySection for Clinical Chemistry, Department of Translational Medicine, Lund University, Sk?ne University Hospital Malm?||Clinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund UniversityDepartment of Pathology, Albert Szent-Gy?rgyi Medical School, University of Szeged||Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of SzegedTherapeutics & Biotechnology Division, Korea Research Institute of Chemical Technology (KRICT)Division of Oncology, Department of Clinical Sciences Lund, Lund UniversityClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund UniversityClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund UniversityDepartment of Dermatology Semmelweis UniversityDepartment of Biochemistry and Biophysics, Karolinska InstituteSection for Clinical Chemistry, Department of Translational Medicine, Sk?ne University Hospital Malm?, Lund UniversityClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund UniversityClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University||Division of Oncology, Department of Clinical Sciences Lund, Lund UniversityDepartment of Molecular Biology, University of Texas Southwestern Medical CenterClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University||First Department of Surgery, Tokyo Medical UniversityDepartment of Dermatology Semmelweis UniversityDepartment of Internal Medicine and Oncology, Semmelweis UniversityChemical Genomics Global Research Lab, Department of Biotechnology, College of Life Science and Biotechnology, Yonsei UniversityDepartment of Pathology, Albert Szent-Gy?rgyi Medical School, University of Szeged||Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged||Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Genome Integrity and DNA Repair Core Group, University of SzegedHCEMM-SU Translational Dermatology Research Group||Department of Physiology, Semmelweis University||Department of Dermatology Semmelweis UniversityDepartment of Biochemistry and Molecular Pharmacology, NYU Grossman School of MedicineClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund UniversitySemmelweis University Department of Bioinformatics||Department of Pediatrics, Semmelweis UniversityChemistry Institute Federal, University of Rio de JaneiroDepartment of Dermatology and Allergology, University of SzegedHCEMM-SU Translational Dermatology Research Group||Department of Physiology, Semmelweis University||Department of Dermatology Semmelweis UniversitySemmelweis University Department of Bioinformatics||Research Centre for Natural Sciences, Institute of Molecular Life SciencesUniversity of Groningen Department of PharmacyDepartment of Dermatology and Allergology, University of SzegedDepartment of Dermatology and Allergology, University of SzegedDivision of Oncology, Department of Clinical Sciences Lund, Lund UniversityDivision of Oncology, Department of Clinical Sciences Lund, Lund UniversityClinical Protein Science & Imaging, Biomedical Centre, Department of Biomedical Engineering, Lund University||Chemistry Institute Federal, University of Rio de JaneiroDepartment of Pathology, Albert Szent-Gy?rgyi Medical School, University of Szeged||Competence Centre of the Life Sciences Cluster of the Centre of Excellence for Interdisciplinary Research, Development and Innovation, University of Szeged||Hungarian Centre of Excellence for Molecular Medicine (HCEMM), Genome Integrity and DNA Repair Core Group, University of Szeged
医药卫生理论医学研究方法肿瘤学
metastatic melanomaimmunotherapyimmunotherapy responserespondersnon-respondersproteomics
Almeida Nat¨￠lia Pinto de,Parada Indira Pla,P¨￠l Dorottya,Lengyel Anna S¨￠ra,Nogueira F¨￠bio,Szasz A. Marcell,Guedes J¨|ssica,Ujfaludi Zsuzsanna,Kim Yonghyo,Baldetorp Bo,Betancourt Lazaro,Appelqvist Roger,K¨￠rp¨￠ti Sarolta,Murillo Jimmy Rodriguez,Malm Johan,Kuras Magdalena,Sanchez Aniel,Paw?owski Krzysztof,MarkoVarga Gy?rgy,Doma Vikt¨?ria,Szeitz Beata,Kwon Ho-Jeong,Pahi Zolt¨￠n G¨￠bor,Kem¨|ny Lajos V.,Feny? David,Gil Jeovanis,Bartha Aron,Domont Gilberto,Szadai Leticia,Lakatos Alexandra,Gy?rffy Bal¨￠zs,Horvatovich Peter,J¨￠nosi ¨￠gnes Judit,N¨|meth Istv¨￠n Bal¨￠zs,Welinder Charlotte,Wieslander Elisabet,Woldmar Nicole,Pankotai Tibor.Predicting immune checkpoint therapy response in three independent metastatic melanoma cohorts[EB/OL].(2025-03-28)[2025-04-29].https://www.biorxiv.org/content/10.1101/2024.05.01.592032.点此复制
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