Risk factors for extended-spectrum beta-lactamase (ESBL) producing E. coli carriage among children in a food animal producing region of Quito, Ecuador
Risk factors for extended-spectrum beta-lactamase (ESBL) producing E. coli carriage among children in a food animal producing region of Quito, Ecuador
Abstract BackgroundThe spread of antibiotic-resistant bacteria may be driven by human-animal-environment interactions, especially in regions with limited restrictions on antibiotic use, widespread food animal production, and free-roaming domestic animals. In this study, we aimed to identify risk factors related to domestic animals, backyard food animals, and commercial food animal production in Ecuadorian communities. Methods & FindingsWe conducted a repeated-measures study from 2018-2021 in 7 semi-rural parishes of Quito, Ecuador to identify determinants of third-generation cephalosporin-resistant E. coli (3GCR-EC) and extended-spectrum beta-lactamase E. coli (ESBL-EC) in children and domestic animals. We used multivariable log-binomial regression models to estimate relative risks (RR) of 3GCR-EC and ESBL-EC carriage. We collected 1,699 child fecal samples from 600 households and 1,871 animal fecal samples from 376 of the same households. Risk factors for 3GCR-EC included living within 5 km of more than 5 commercial food animal operations (RR: 1.36; 95% Confidence Interval: 1.16, 1.59), household pig ownership (1.23; 1.02, 1.48), child pet contact (1.23; 1.09, 1.39), and rarely/never washing hands after contact with animals (1.15; 0.98, 1.34). Risk factors for ESBL-EC were dog ownership (1.43; 1.00, 2.04), child pet contact (1.54; 1.10, 2.16), placing animal feces on household land/crops (1.63; 1.09, 2.46), and combined exposures to both household food animals and commercial food animal operation drainage paths (1.80; 0.94, 3.45). ConclusionsPolicies and interventions that improve the safety of animal waste management in communities and in commercial food animal production operations may be necessary to curb the spread of resistant bacteria.
Loayza Fernanda、Garcia Daniela、Pickering Amy J.、Saraiva-Garcia Carlos、Trueba Gabriel、Johnson Timothy J.、Graham Jay P.、Salinas Liseth、Sarzosa Soledad、Riley Lee W.、Paredes Diana、Amato Heather K.
Instituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoAmy J. Pickering, Department of Civil and Environmental Engineering, University of California Blum Center for Developing Economies, University of CaliforniaInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoDepartment of Veterinary and Biomedical Sciences, University of Minnesota Mid Central Research & Outreach CenterEnvironmental Health Sciences Division, School of Public Health, University of CaliforniaInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoDivision of Infectious Diseases and Vaccinology, School of Public Health, University of CaliforniaInstituto de Microbiolog¨aa, Colegio de Ciencias Biol¨?gicas y Ambientales, Universidad San Francisco de QuitoEnvironmental Health Sciences Division, School of Public Health, University of California
医药卫生理论医学研究方法微生物学
One HealthE. coliESBLantibiotic resistancefood animalsEcuador
Loayza Fernanda,Garcia Daniela,Pickering Amy J.,Saraiva-Garcia Carlos,Trueba Gabriel,Johnson Timothy J.,Graham Jay P.,Salinas Liseth,Sarzosa Soledad,Riley Lee W.,Paredes Diana,Amato Heather K..Risk factors for extended-spectrum beta-lactamase (ESBL) producing E. coli carriage among children in a food animal producing region of Quito, Ecuador[EB/OL].(2025-03-28)[2025-05-01].https://www.medrxiv.org/content/10.1101/2022.11.14.22282279.点此复制
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