胃肠胰神经内分泌肿瘤临床流行病学研究
he epidemiology of gastroenteropancreatic neuroendocrine
目的：本课题通过回顾性分析胃肠胰神经内分泌肿瘤患者的特征，总结胃肠胰神经内分泌肿瘤临床流行病学特点。方法：回顾性分析168例胃肠胰神经内分泌肿瘤患者的临床、病理资料。结果：患者平均年龄为51.8±14.0 岁，男女性别比为1.5:1。168例患者其常见的发病部位为直肠，最常见的症状为腹部或后背疼，胃镜是目前临床中常用的影像学检查方式，患者平均生存时间为8.9±0.3 年。多因素分析显示，肿瘤直径和肿瘤类型为独立预后影响因素结论：胃肠胰神经内分泌肿瘤以非功能性神经内分泌肿瘤居多，且无典型临床症状和体征。手术治疗仍然是这类肿瘤主要的治疗方式。胃肠胰神经内分泌肿瘤患者总体预后较好，但原发肿瘤大小和肿瘤分级不同将显著影响患者生存。
Objective: The aim of this retrospective study was to describe clinical,pathological and prognostic characteristics of GEP-NENs. Methods: We collected the clinical and pathological data of 168 patients. Results: Mean age was 51.8±14.0 and the male-to-female ratio was 1.5:1. Most primary site was the rectum, and the majority of patients back pain, the highest positive tested rate was endoscopy. The estimated mean overall survival was 8.94±0.28 years. Multivariate analysis confirmed that tumor size and tumor type were the only independent prognostic factors for survival. Conclusion：Non-functional tumors account for most of the GEP-NENs and most of them did not have significant clinical symptoms and main signs. Thediagnosis of GEP-NENs mainly depends on digestive endoscopy, pathologic biopsy and immunohistochemistry. Surgery is the main treatment and the effect is satisfactory. The prognosis of GEP-NENs is excellent; however, different tumor size and tumor type influenced survival significantly.
董鑫、刘鹏、巩鹏、张贤彬、曹飞
肿瘤学临床医学内科学
神经内分泌肿瘤类癌临床流行病学治疗预后
Neuroendocrine neoplasm Carcinoma Epidemiology Treatment Prognosis
董鑫,刘鹏,巩鹏,张贤彬,曹飞.胃肠胰神经内分泌肿瘤临床流行病学研究[EB/OL].(2016-06-03)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201606-305.点此复制
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