E序贯125I放射性粒子植入治疗中晚期肝癌疗效对比观察

Objective: To compare the curative effect of sample TACE and TACE sequential 125I radioactive particles implantation in the treatment of Hepatic Carcinoma. Methods: 94 cases of Hepatic Carcinoma were retrospectively collected from May 2011 to May 2012.During the period 5 cases were lost to be follow for various reasons,and 89 cases were collected. All cases collected were divided into group A (45 patients with TACE alone) and group B (44 patients with TACE sequential 125I radioactive particles implantation). According to the Response Evaluation Criteria in Solid Tumors (RECIST) and the Response Evaluation Criteria in Specification of Comprehensive Interventional Treatment for Liver Cancer ,efficacy evaluation was performed in 2 months, 4 months after the operation by CT scan. Recorded the survival status of 4 months9months.Two groups's Efficacy evaluation and survival status were compared by chi-suqare test, with statistically significant difference ( P<0.05). Results The OR(CR+PR) of group A were 24.44%(11/45), 17.78%(8/45)，and group B were 54.55%(24/44），47.73%（21/44）respectively at 2 months,4months after operation with significant difference( P<0.05). The survival rate at 6, 9 months in group A (62.22%, 42.22%） were significantly lower than those in group B (90.91%, 72.73%), P<0.05. Conclusion Transcatheter hepatic arterial chemoembolization sequential 125I radioactive particles implantation is an effective method for the treatment of Hepatic Carcinoma, which can also improved survival rate.