The continuous differentiation of multiscale structural gradients from childhood to adolescence correlates with the maturation of cortical morphology and functional specialization
Zhao Tengda 1He Yirong 2Li Qiongling 1Sun Lianglong 1Wang Yanpei 2Wang Daoyang 3Hu Mingming 2Tan Shuping 4Li Shuyu 2Dong Qi 2He Yong 5Lei Tianyuan 1Zeng Debin 6Liang Xinyuan 1Zhang Haibo 2Gao Jia-Hong 7Pan Zhiying 2Dong Xiaoxi 2Liao Xuhong 8Tao Sha 2Chen Xiaodan 1Men Weiwei 9Qin Shaozheng 5Chu Lei 6Liu Ningyu2
作者信息
- 1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University||Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University||IDG/McGovern Institute for Brain Research, Beijing Normal University
- 2. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University
- 3. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University||Zhejiang Philosophy and Social Science Laboratory for Research in Early Development and Childcare, Hangzhou Normal University
- 4. Beijing Huilongguan Hospital, Peking University Huilongguan Clinical Medical School
- 5. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University||Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing Normal University||IDG/McGovern Institute for Brain Research, Beijing Normal University||Chinese Institute for Brain Research
- 6. Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science & Medical Engineering, Beihang University
- 7. Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University||Beijing City Key Laboratory for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University||IDG/McGovern Institute for Brain Research, Peking University
- 8. School of Systems Science, Beijing Normal University
- 9. Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University||Beijing City Key Laboratory for Medical Physics and Engineering, Institute of Heavy Ion Physics, School of Physics, Peking University
- 折叠
Abstract
Abstract
From childhood to adolescence, the structural organization of the human brain undergoes dynamic and regionally heterogeneous changes across multiple scales, from synaptic pruning to the reorganization of large-scale anatomical wiring. However, during this period, the developmental process of multiscale structural architecture, its association with cortical morphological changes, and its role in the maturation of functional organization remain largely unknown. Here, we utilized a longitudinal multimodal imaging dataset including 276 children aged 6 to 14 years to investigate the developmental process of multiscale cortical wiring. We used an in vivo model of cortical wiring that combines features of white matter tractography, cortico–cortical proximity, and microstructural similarity to construct a multiscale brain structural connectome. By employing the gradient mapping method, the gradient space derived from the multiscale structural connectome effectively recapitulated the sensory-association axis and anterior-posterior axis. Our findings revealed a continuous expansion of the multiscale structural gradient space during development, with the principal gradient increasingly distinguishing between primary and transmodal regions. This age-related differentiation coincided with regionally heterogeneous changes in cortical morphology. Furthermore, our study revealed that developmental changes in coupling between multiscale structural and functional connectivity were correlated with functional specialization refinement, as evidenced by changes in the participation coefficient. We also found that the differentiation of the principal multiscale structural gradient was associated with improved cognitive abilities, such as enhanced working memory and attention performance, and potentially supported by molecular processes related to synaptic functions. These findings advance our understanding of the intricate maturation process of brain structural organization and its implications for cognitive performance.Key words
Brain development/structural connectome gradient/sensorimotor-association cortical axis/brain morphology引用本文复制引用
Zhao Tengda,He Yirong,Li Qiongling,Sun Lianglong,Wang Yanpei,Wang Daoyang,Hu Mingming,Tan Shuping,Li Shuyu,Dong Qi,He Yong,Lei Tianyuan,Zeng Debin,Liang Xinyuan,Zhang Haibo,Gao Jia-Hong,Pan Zhiying,Dong Xiaoxi,Liao Xuhong,Tao Sha,Chen Xiaodan,Men Weiwei,Qin Shaozheng,Chu Lei,Liu Ningyu.The continuous differentiation of multiscale structural gradients from childhood to adolescence correlates with the maturation of cortical morphology and functional specialization[EB/OL].(2025-03-28)[2026-04-03].https://www.biorxiv.org/content/10.1101/2024.06.14.598973.学科分类
神经病学、精神病学/基础医学/生物科学研究方法、生物科学研究技术
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