Dynamics of corticocortical brain functional connectivity relevant to therapeutic response to biologics in inflammatory arthritis
Dynamics of corticocortical brain functional connectivity relevant to therapeutic response to biologics in inflammatory arthritis
ABSTRACT ObjectivesBrain function controls cognition and pain perception. The dynamics of brain function also affects physiopsychological status in individuals with neuropsychiatric diseases or chronic pain, and could be evaluated by functional magnetic resonance imaging (fMRI). The brain functional connectivity is aberrant in inflammatory arthritis (IA) including rheumatoid arthritis and spondyloarthritis. We aimed to evaluate the effects of dynamic functional connectivity on clinical course of IA in the context of therapeutic responsiveness to biologics using resting-state fMRI. MethodsResting-state fMRI data from 64 patients with IA consisting of two cohorts were used. Dynamic functional connectivity was derived as a correlation coefficient of the windowed blood oxygen level-dependent signal time series. We determined representative whole-brain functional connectivity patterns by k-means++ cluster analysis, and evaluated the association of their occurrence probability and therapeutic outcomes with biologics. ResultsFour distinct clusters of dynamic functional connectivity in IA patients were determined. In the first cohort, occurrence probability of cluster 3 was associated with favorable therapeutic response in disease activity and patients’ global assessment. This finding was validated by the second cohort. The whole-brain functional coordination of the cluster 3 indicated significantly increased corticocortical connectivity, and probabilistically decreased after therapy in treatment-effective patients compared to -ineffective patients. ConclusionDynamic functional connectivity, in particular, frequent emergence of corticocortical connections was associated with clinical outcomes in patients with IA. Our study suggested that the coherence of corticocortical interactions is related to top-down modulation of pain and therapeutic satisfaction, and give significant perspective for brain function in IA management.
Kono Michihito、Kanda Masatoshi、Sakiyama Kodai、Karino Kohei、Atsumi Tatsuya、Kato Masaru、Abe Nobuya、Fujieda Yuichiro、Narita Hisashi、Tha Khin K.
Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University||Department of Rheumatology and Clinical Immunology, School of Medicine, Sapporo Medical UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Psychiatry, Faculty of Medicine, Hokkaido UniversityDepartment of Diagnostic and Interventional Radiology, Hokkaido University Hospital||Global Centre for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University
神经病学、精神病学基础医学医学研究方法
resting-state functional magnetic resonance imagingdynamic functional connectivityneuroimagingrheumatoid arthritisspondyloarthritisbiologicsinflammatory arthritisdisease activitybrain function
Kono Michihito,Kanda Masatoshi,Sakiyama Kodai,Karino Kohei,Atsumi Tatsuya,Kato Masaru,Abe Nobuya,Fujieda Yuichiro,Narita Hisashi,Tha Khin K..Dynamics of corticocortical brain functional connectivity relevant to therapeutic response to biologics in inflammatory arthritis[EB/OL].(2025-03-28)[2025-05-08].https://www.medrxiv.org/content/10.1101/2022.05.15.22275083.点此复制
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