In response to Li et al. : Linker histones function in Drosophila embryogenesis
In response to Li et al. : Linker histones function in Drosophila embryogenesis
ABSTRACT In an earlier paper (Pérez-Montero et al., 2013), we reported that the embryonic linker histone of Drosophila dBigH1 was essential for early Drosophila embryogenesis since embryos homozygous for the bigH1100 mutation showed strong defects and did not survive beyond zygotic genome activation (ZGA) at cellularization. Recent results challenge these observations since null bigH1 mutations generated by CRISPR/Cas9 methodology turn out to be homozygous viable, as reported in Li et al. (2019) and here. In this regard, Li et al. described a novel mechanism by which lack of dBigH1 is compensated by the early expression of maternal dH1. Here, we confirm this observation and show that such compensatory mechanism is not activated in bigH1100 embryos.
Szab¨? Anik¨?、P¨|rez-Rold¨￠n Juan、Boros Imre M.、Henn Lazslo、Carbonell Albert、Tamirisa Srividya、Azor¨an Fernando
Institute of Biochemistry, Biological Research Centre of Szeged||Doctoral School in Biology, Faculty of Science and Informatics, University of SzegedInstitute of Molecular Biology of Barcelona, IBMB, CSIC. Baldiri Reixac||Institute for Research in Biomedicine, IRB Barcelona. The Barcelona Institute of Science and Technology. Baldiri ReixacInstitute of Biochemistry, Biological Research Centre of Szeged||Department of Biochemistry and Molecular Biology, Faculty of Science and Informatics, University of SzegedInstitute of Biochemistry, Biological Research Centre of SzegedInstitute of Molecular Biology of Barcelona, IBMB, CSIC. Baldiri Reixac||Institute for Research in Biomedicine, IRB Barcelona. The Barcelona Institute of Science and Technology. Baldiri ReixacInstitute of Molecular Biology of Barcelona, IBMB, CSIC. Baldiri Reixac||Institute for Research in Biomedicine, IRB Barcelona. The Barcelona Institute of Science and Technology. Baldiri ReixacInstitute of Molecular Biology of Barcelona, IBMB, CSIC. Baldiri Reixac||Institute for Research in Biomedicine, IRB Barcelona. The Barcelona Institute of Science and Technology. Baldiri Reixac
遗传学细胞生物学分子生物学
linker histone H1dBigH1chromatinembryogenesisZGADrosophila
Szab¨? Anik¨?,P¨|rez-Rold¨￠n Juan,Boros Imre M.,Henn Lazslo,Carbonell Albert,Tamirisa Srividya,Azor¨an Fernando.In response to Li et al. : Linker histones function in Drosophila embryogenesis[EB/OL].(2025-03-28)[2025-05-28].https://www.biorxiv.org/content/10.1101/2020.03.21.001529.点此复制
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