视网膜内的神经递质
Neurotransmitters in the retina
视网膜内几乎含有大脑内所有的神经递质，包括氨基酸类：谷氨酸（Glutamate，Glu）、γ-氨基丁酸（γ-aminobutyric acid ，GABA）、天冬氨酸、甘氨酸、乙酰胆碱；单胺类：多巴胺、5-羟色胺；肽类：缩胆囊素、脑啡肽、高血糖素、神经紧张素、神经肽Y、生长抑素、P物质、血管活性肠肽；还有其他一些调节剂，如一氧化氮、维甲酸、锌等。其中谷氨酸、γ-氨基丁酸、甘氨酸、多巴胺和5-羟色胺为视网膜内主要的神经递质，对维持视网膜正常功能起着非常重要的作用。本文将综述视网膜内主要神经递质的生物合成、代谢、功能及其在病理条件下的变化。
lmost all kinds of neurotransmitters exsited in brain are also discovered in the retina, including amino acids neurotransmitters (glutamate, γ-aminobutyric acid, aspartate, glycine and acetylcholine), monoamine neurotransmitters (dopamine, serotonin), peptide (cholecystokinin, enkephalin, glucagon, neurotensin, neuropeptide Y ), and neuromodulations (nitric oxide, retinoic acid, zinc ion). Glutamate,γ-aminobutyric acid, glycine, dopamine and serotonin are the major neurotransmitters in retina, which are important to the normal function of retina. Here, we would review the biosynthesis, metabolism, function and changes in pathological conditions of the major neurotransmitters in retina.
罗佳、周利红、陈旦、黄菊芳、王慧
眼科学基础医学生理学生物化学
神经生物学视网膜神经递质
neurobiologyretinaneutotransmitters
罗佳,周利红,陈旦,黄菊芳,王慧.视网膜内的神经递质[EB/OL].(2012-09-13)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201209-130.点此复制
评论