巯基修饰不同孔径SBA-15对溶菌酶吸附和释放的动力学模型拟合

Mesoporous material SBA-15 of large pore size were synthesized by the usage of swelling agent. After thiol-modification, the mesoporous materials were used as the support in the adsorption of lysozyme. The loading and release process of LYZ on the material with different conditions were investigated. In this article, different models (Pseudo-First-Order, Pseudo-Second-Order, Intraparticle Diffusion, Elovich Equation, Bangham Equation) have been analyzed for there suitability to depict lysozyme adsorption kinetics on the thiol-functioned SBA-15. The dynamics is estimated by matching the models with the experimental data. The dependence of the initial protein concentration on the quantity and rate of adsorption of lysozyme is observed and discussed. The process of the adsorption of LYZ is complicated because there are several mechanisms take effect at the same time. For thiol-functioned SBA-15, the maximum equilibrium adsorption amount could be observed within 48h. The influence of the pore size on the loading capacity is not distinct. The release exhibited a good and sustained manner and was controlled by solution pH. For release from the material having a porosity matrix, according to the theoretical analysis of Higuchi. The release profiles exhibited a pronounced initial burst release effect of about 30%, followed by a slow release pattern.