喹唑啉和喹唑啉酮衍生物合成研究进展

Quinazoline and quinazolinone derivatives widely found in natural products are important two kinds of N-heterocycles, and they have exhibited various biological and pharmacological activities such as anti-cancer, anti-virus and anti-tuberculosis functions, so they have been applied as drugs and pesticides. This review focuses on the advance in synthesis of quinazoline and quinazolinone derivatives including use of substrates, reaction conditions, advantages in the methods, and some important mechanisms are provided. Finally, the future development for synthesis of quinazoline and quinazolinone derivatives is also discussed.