骨胶原多肽对小鼠抗氧化能力和皮肤、骨骼胶原蛋白mRNA表达的影响

Purpose] To explore the influence of ossein peptide (OP) on the antioxidant capacity and collagen mRNA expression of skin and bone in high-fat-diet km mice. [Methods] 75 KM mice were randomly assigned to 5 groups, which respectively control group, high-fat-diet group, lipoic acid (LA) group, 1%OP group and 2%OP group. All mice were sacrificed at the end of 16ws, 100 mg skin were taken for the measurement of antioxidant capacity, 100 mg skin and heads of left femurs were taken for collagen genes expression. [Results] High-fat-diet could weaken antioxidant capacity, decrease collagen genes expression in skin and femur. In contrast, OP could decrease the ROS level and MDA content significantly (P<0.05), strengthen the activity of CAT, T-AOC and up-regulated the main kinds of collagen mRNA expression in skin and femur (P<0.05) significantly. High does OP can recover most of the indicators to normal level, LA also worked, but the effects were not as good as OP. [Conclusion] The supplements of OP could improve antioxidant capacity and collagen mRNA expression,and the close relationship between the body's redox status and collagen metabolism was also be confirmed.