氯己定及其类似物对鲍曼不动杆菌抑制的构效关系研究
Research on the structure-activity relationship of chlorhexidine and its analogs against A. baumannii inhibition
目的：研究氯己定以及合成的氯己定类似物对临床分离的鲍曼不动杆菌的活性，在此基础上进一步探究它们对鲍曼不动杆菌抑制的构效关系。方法：在参考文献的基础上合成一系列氯己定类似物，并利用微量液体稀释法在96孔板中测试它们对两株临床分离的鲍曼不动杆菌的最小抑菌浓度（minimal inhibitory concentration，MIC）。根据所获得的MIC值来进一步讨论它们对鲍曼不动杆菌抑制的构效关系。结果：对氯己定及其类似物而言，中间链的长度，端基链的长度以及对称的双胍阳离子基团对其抗菌活性都有很大的影响。
Objective: To determine the antibacterial activity of chlorhexidine and its analogs against two clinical isolates of A. baumannii, and to further explore their structure-activity relationship against A. baumannii inhibition. Methods: A series of chlorhexidine analogs were synthesized according to reported references, and their minimal inhibitory concentration (MIC) against two clinical isolates of A. baumannii was tested in a 96-well plate using the microscale broth dilution method. Their corresponding structure-activity relationship inA. baumannii inhibtion was discussed according to the obtained MIC values. Results: For chlorhexidine and its analogs, the length of the linker, the length of the terminal chain and the symmetrical biguanidine cationic group all had a great influence on their antibacterial activity against A. baumannii.
冯欣欣、雷娥
药学基础医学微生物学
鲍曼不动杆菌氯己定最小抑菌浓度（MIC）脂质A结构-活性关系
. baumanniiChlorhexidineMinimum inhibitory concentration (MIC)Lipid AStructure-activity relationship
冯欣欣,雷娥.氯己定及其类似物对鲍曼不动杆菌抑制的构效关系研究[EB/OL].(2021-05-21)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/202105-159.点此复制
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