阿尔茨海默病神经元细胞周期再进入的研究进展

Backgrounds: At present, hypotheses of pathological mechanism of Alzheimer's disease(AD) include A β deposition, abnormal Tau protein phosphorylation, oxidative stress and inflammation. But none of above hypotheses can explain all the pathological features of AD. Current Status: "Neurodegeneration-cell cycle" hypothesis has broken the past theory of "neurons were in a state of terminal differentiation after mitotic division", which puts forward that neurons may proliferate and re-enter cell cycle in neurodegeneration and other pathological conditions. But neurons forced back into cell cycle of could not continue to differentiate, but to death. Re-entering cell cycle of damaged neurons in AD has been confirmed to be one of earliest pathological features of AD. Cell cycle regulation abnormality, which appears earlier than neurofibrillary tangles and senile plaques, may be associated with all pathologic features of AD and continues throughout the course of AD. Research Purposes: "Neurodegeneration-cell cycle" hypothesis might contribute to explain pathological mechanism, diagnosis and therapy of AD.