褪黑素与乳腺癌雌激素受体表达的相关性分析

Objective To study the effect of melatonin on the expression of estrogen receptor in rats breast cancer, and to analyzethe role of melatonin in the development of breast cancer. Methods Ninety female rats of clean grade SD in age 2 months wereselected, and the breast cancer cells were inoculated in the rats. The rats were randomly divided to control group injected withsaline, group injected with melatonin at a dose of 7.5 mg/(kg), group injected with melatonin at a dose of 15 mg/(kg). Thebreast cancer tumor bearing models of rats were established on the 10th day after inoculating, and the tissues of breast cancerwere taken out. The expression of estrogen receptor in breast cancer was detected by immunohistochemistry method. ResultsThe estrogen receptor expression index of rats breast cancer tissues in the group injected with melatonin was lower than that inthe control group injected with saline, the estrogen receptor expression index further decreased with the increase of the dose ofmelatonin. Above differences were statistically significant. Conclusion Melatonin can inhibit the expression of estrogenreceptor in breast cancer tissues, which may be one of the ways to prevent the development of breast cancer.