组蛋白修饰与结直肠癌
Histone Modifications and Colorectal Cancer
结直肠癌是一种消化道恶性肿瘤，它的发生机制尚未完全阐述清楚。近几年研究表明，组蛋白修饰尤其是乙酰化和甲基化在结直肠癌的发生、发展中发挥重要作用。本文综述了组蛋白乙酰化、甲基化与结直肠癌的关系以及循环核小体中组蛋白修饰模式是否能作为检测结直肠癌发生发展的候选标志物。?????
IColorectal cancer (CRC) is a kind of malignant tumor of alimentary system, but its pathogenesis has not been completely cleared. Recntly, some studies reported that histone modifications, especially acetylation and methylation, play an important role in the development of CRC. In this review, we discuss the relationship between histone modification （acetylation or methylation） and CRC, and whether histone modification patterns in circulating nucleosomes can be a potential biomarker for CRC examination.
赵治宇、陈滢、程永娜、王硕、杨艳梅
肿瘤学基础医学分子生物学
组蛋白修饰循环核小体结直肠癌组蛋白甲基化组蛋白乙酰化?????
Histone modificationsirculating nucleosomesolorectal CancerHistone methylationHistone acetylation ?????
赵治宇,陈滢,程永娜,王硕,杨艳梅.组蛋白修饰与结直肠癌[EB/OL].(2015-05-19)[2025-08-11].http://www.paper.edu.cn/releasepaper/content/201505-244.点此复制
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