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紫苏叶提取液灌胃的抗组胺过敏反应的初步研究

Preliminary study on anti histamine allergic reaction was perfused from perilla leaf

中文摘要英文摘要

紫苏作为我国传统的药食植物,其主要的化学成分之一--黄酮具有解热镇静、抗炎、抗过敏、止血、等多方面的生物活性。但在我国对其抗过敏性质的研究较少。而食物过敏是非常常见的现象,症状轻重不一,对人有不同程度的危害。因此,实验研究紫苏对过敏的生理效应,即采用致敏制剂磷酸组胺(海鲜等致敏食物经人体消化后血液中的主要致敏物),对兔子进行静脉注射,间隔一段时间之后,再用紫苏熬制液灌喂兔子,与灌喂市售抗过敏药物氯雷他定片水溶液的治疗效果形成对比,通过测量血中IgE的动态变化(因IgE能直观地反映过敏是否产生,排除人为观察动物表观现象的误差),得出紫苏有治疗过敏的效果;另外,实验还测量了紫苏对过敏的预防效果,即先给兔子灌喂紫苏熬制液,经过一段时间后,注射磷酸组胺,与氯雷他定片的预防效果形成对比,同样测量血中IgE的数值,从中得出紫苏还有预防过敏产生的效果。

Perilla as traditional Chinese medicine and food plant, one of the main chemical constituents of flavonoids with the biological activity of antipyretic, sedative, anti-inflammatory, anti allergy, hemostasis, etc.. However, there are few studies on its anti allergic properties in our country. And food allergy is a very common phenomenon, the severity of the symptoms vary, there are different degrees of harm to people. Therefore, experimental study on physiological effect of Perilla allergy, namely the sensitized preparation of histamine phosphate (seafood and other food allergens by digestion in the blood of the main allergens), intravenous injection of rabbit, after a period of time interval, and then decocted liquid fed perilla rabbit, in contrast with the Fed city the sale of anti allergic drugs Loratadine Tablets water solution treatment, the dynamic changes in blood IgE measurement (because IgE can directly reflect whether to exclude human allergy, animal observation error phenomenon, the concept) perilla allergy effect; in addition, the experiment also measured the preventive effect of Perilla allergy, i.e. give the rabbit fed perilla brewed liquor, after a period of time after the injection of histamine phosphate, in contrast to the preventive effect of Loratadine Tablets, the same numerical measurement of blood IgE, from which The effect of perilla and allergy.

林瑞余、陈伟军

药学中医学基础医学

海鲜过敏紫苏磷酸组胺免疫球蛋白E(IgE)

Seafood allergyPerillahistamineimmunoglobulin E (IgE)

林瑞余,陈伟军.紫苏叶提取液灌胃的抗组胺过敏反应的初步研究[EB/OL].(2016-04-21)[2025-07-22].http://www.paper.edu.cn/releasepaper/content/201604-272.点此复制

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