真菌碳代谢抑制机制研究进展

In this paper，carbon catabolite repression is a wide domain regulatory system that responds to the multiple environment to regulate carbon metabolism. At present, although the mechanism of CCR has been well studied in bacteria, CCR in fungi needs more further studies . Comparatively speaking, in fungi, the multicopy inhibitor of glucose(Mig1) in Saccharomyces cerevisiae, carbon metabolism regulation network composed of CreA, B, C, D in Aspergillus nidulans and carbon catabolite repressor CRE1 of Trichoderma.spp are research hotspots that has been studied for decades and get much advancement. There are some similarities in part of three CCR mechanisms, but still have more differences among them. And furthermore, as an important transcriptional regulator of fungi cells, CCR play a diversiform role in growth and metabolism, especially the expressions and activities of carbohydrate-active enzymes, transporters, and transcriptional factors, etc. The purpose of this review then is to compare the similarities and differences of CCR mechanisms in these two types of fungi, mainly utilizing information gained from genomics in order to highlight the importance of the CCR in these important model microorganisms.