猪松质骨制备骨修复工程支架材料

Sintered porcine cancellous bone kept intrinsic porous structure with excellent biocompatiblity, high porosity and have an interconnecting allowing for bone ingrowth. However, the main mineral constitution of sintered porcine bone-hydroxyapatite (Ca10(PO4)6(OH)2, HAP) seems to be bad biodegradability in vivo. For improving its bioactivity, the calcined porcine bone-removing the organic substance by burning process with different quantities of NH4)2HPO4 addition was heated to a high temperature to transform its crystalline phase constitution from HAP into TCP/HAP biphasic or other multiphasic structures. Cell culture results in vitro show that the prepared materials exhibit fine biocompatibility suitable for adhesion and proliferation of the cells with no cytotoxicity, It is good for bone tissue engineering scaffolds.