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祛痰逐水法对实验性急性肺损伤大鼠的影响

Protective effect of eliminating phlegm and fluid-purging exercise on lipopolysaccharide induced acute lung injury in rats

中文摘要英文摘要

目的:从《伤寒论》结胸证治的提示,探讨祛痰逐水法对大鼠内毒素性急性肺损伤(ALI)的影响。方法:脂多糖诱发ALI,随机分为5组,即模型组、十枣汤组、三物白散组、大陷胸汤组和空白对照组。检测大鼠肺组织湿干比、血清TNF-α以及组织病理学。结果:模型组肺组织湿干比高于药物干预组和空白组(p<0.05);血清TNF-α模型组也明显高于药物组和空白组(p<0.05);组织病理学损害药物组也较模型组轻。结论:祛痰逐水法能减轻实验性急性肺损伤大鼠的损伤。

Objective: to study theprotective effect of eliminating phlegm and fluid-purging exercise on acute lung injury induced by lipopolysaccharide in rats. Methods: All models of rats were reproduced by injecting lipopilysaccharide into the vein. 40 male Wistar rats were randomly divided into 5groups: LPS group, control group, Shizaotang treatment group, Sanwubaisan treatment group and Daxianxiongtang treatment group. Tumor necrosis factor –α(TNF-α) level in serum,and W/D were measured, respectively. Results: (TNF-α) level in serum is higher in LPS group than those in the control group (all p<0.05). The pathologic changes of lung tissue under microscope in control group were higher than those in LPS group. Conclusion: It is suggested that qutanzhushui fang can protect the lung of experimental ALI model.

陆健 、区永欣、古继红、张小虎

中医学基础医学内科学

祛痰逐水动物实验内毒素急性肺损伤

eliminating phlegm and fluid-purging exerciseratlipopolysaccharideacute lung injury

陆健 ,区永欣,古继红,张小虎.祛痰逐水法对实验性急性肺损伤大鼠的影响[EB/OL].(2007-04-29)[2025-08-18].http://www.paper.edu.cn/releasepaper/content/200704-745.点此复制

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