SARS-CoV-2 infection in pregnancy in Denmark – characteristics and outcomes after confirmed infection in pregnancy: a nationwide, prospective, population-based cohort study
SARS-CoV-2 infection in pregnancy in Denmark – characteristics and outcomes after confirmed infection in pregnancy: a nationwide, prospective, population-based cohort study
Abstract IntroductionAssessing the risk factors for and consequences of infection with SARS-CoV-2 during pregnancy is essential to guide clinical guidelines and care. Previous studies on the influence of SARS-CoV-2 infection in pregnancy have been among hospitalised patients, which may have exaggerated risk estimates of severe outcomes because all cases of SARS-CoV-2 infection in the pregnant population were not included. The objectives of this study were to identify risk factors for and outcomes after SARS-CoV-2 infection in pregnancy independent of severity of infection in a universally tested population, and to identify risk factors for and outcomes after severe infection requiring hospital admission. Material and MethodsThis was a prospective population-based cohort study in Denmark using data from the Danish National Patient Register and Danish Microbiology Database and prospectively registered data from medical records. We included all pregnancies between March 1 and October 31, 2020 and compared women with a positive SARS-CoV-2 test during pregnancy to non-infected pregnant women. Cases of SARS-CoV-2 infection in pregnancy were both identified prospectively and through register linkage to secure that all cases were identified and that cases were pregnant during infection. Main outcome measures were pregnancy, delivery, maternal, and neonatal outcomes. Severe infection was defined as hospital admission due to COVID-19. ResultsAmong 82 682 pregnancies, 418 women had SARS-CoV-2 infection during pregnancy, corresponding to an incidence of 5.1 per 1000 pregnancies, 23 (5.5%) of which required hospital admission due to COVID-19. Risk factors for infection were asthma (OR 2.19 [1.41–3.41]) and being foreign born (OR 2.12 [1.70–2.64]). Risk factors for hospital admission due to COVID-19 included obesity (OR 2.74 [1.00–7.51]), smoking (OR 4.69 [1.58–13.90]), infection after gestational age (GA) 22 weeks (GA 22–27 weeks: OR 3.77 [1.16–12.29]; GA 28–36 weeks: OR 4.76 [1.60–14.12]) and having asthma (OR 4.53 [1.39–14.79]). We found no difference in any obstetric or neonatal outcomes. ConclusionsOnly 1 in 20 women with SARS-CoV-2 infection during pregnancy require admission to hospital due to COVID-19. And severe outcomes of SARS-CoV-2 infection in pregnancy are rare. Key MessagePopulation based cohort study about SARS-CoV-2 infection during pregnancy. Asthma and foreign ethnicity were identified as risk factors for infection while obstetric outcomes did not change. Obesity, smoking, infection after GA 22, and asthma increased the risk of hospital admission.
Rubin Katrine H、Br¨1lle Anne-Line、Rathcke Sidsel L、Petersen Lone K、Bliddal Mette、Petersen Tanja G、Corn Giulia、Jonsdottir Fjola、Andersen Charlotte S、Sundtoft Iben、Milbak Julie、Khalil Mohammed R、Henriksen Birgitte、Andersen Lise LT、Vestgaard Marianne、Krebs Lone、J?nsson Lisbeth、Thorsen-Meyer Annette、Stokholm Lonny、Andersen Line S、Tatla Manrinder K、J?rgensen Jan S、Clausen Tine、Kjeldsen Frank S、Hansen Lea、Farlie Richard、Burmester Lars、Gulbech Arense、Thisted Dorthe、Ibsen Mette H、W?jdemann Karen、Andersson Charlotte B、S?rensen Anne N、Aabakke Anna JM、R?nneberg Elisabeth、Lindved Birgitte、Klemmensen ?se、Karlsen Kamilla K、Pedersen Monica L、Hvidman Lone
OPEN - Open Patient data Explorative Network, Odense University Hospital||Department of Clinical Research, University of Southern DenmarkDepartment of Obstetrics and Gynecology, Hospital of South JutlandDepartment of Obstetrics and Gynecology, Aalborg University HospitalDepartment of Obstetrics and Gynecology, Odense University Hospital||Department of Clinical Research, University of Southern DenmarkOPEN - Open Patient data Explorative Network, Odense University Hospital||Department of Clinical Research, University of Southern DenmarkOPEN - Open Patient data Explorative Network, Odense University HospitalDepartment of Epidemiology Research and Division of Infectious Diseases Preparedness, Statens Serum InstitutDepartment of Obstetrics and Gynecology, Copenhagen University Hospital ¨C Herlev and GentofteDepartment Obstetrics and Gynecology, Regional Hospital West JutlandDepartment Obstetrics and Gynecology, Regional Hospital West JutlandDepartment of Obstetrics and Gynecology, Copenhagen University Hospital ¨C North ZealandDepartment Obstetrics and Gynecology, University Hospital of Southern Denmark ¨C KoldingDepartment Obstetrics and Gynecology, University Hospital of Southern Denmark ¨C KoldingDepartment of Obstetrics and Gynecology, Odense University HospitalDepartment of Obstetrics and Gynecology, Copenhagen University Hospital - RigshospitaletDepartment of Clinical Medicine, University of Copenhagen||Department of Obstetrics and Gynecology, Copenhagen University Hospital ¨C Amager and HvidovreDepartment Obstetrics and Gynecology, Nyk?bing F. Hospital, Nyk?bing FDepartment of Obstetrics and Gynecology, Copenhagen University Hospital ¨C Amager and HvidovreOPEN - Open Patient data Explorative Network, Odense University Hospital||Department of Clinical Research, University of Southern DenmarkDepartment of Obstetrics and Gynecology, Copenhagen University Hospital - SlagelseDepartment of Obstetrics and Gynecology, Zealand University HospitalDepartment of Obstetrics and Gynecology, Odense University Hospital||Department of Clinical Research, University of Southern DenmarkDepartment of Clinical Medicine, University of Copenhagen||Department of Obstetrics and Gynecology, Copenhagen University Hospital ¨C North ZealandOPEN - Open Patient data Explorative Network, Odense University HospitalDepartment of Obstetrics and Gynecology, Aarhus University HospitalDepartment of Obstetrics and Gynecology, Viborg Regional HospitalDepartment of Obstetrics and Gynecology, The North Denmark Regional Hospital Hj?rringDepartment of Obstetrics and Gynecology, Hospital of South JutlandDepartment of Obstetrics and Gynecology, Zealand University HospitalDepartment Obstetrics and Gynecology, Hospital of South West JutlandDepartment of Obstetrics and Gynecology, Copenhagen University Hospital - BornholmDepartment of Obstetrics and Gynecology, The North Denmark Regional Hospital Thisted||Danish Center for Clinical Health Services Research (DACS)Department of Obstetrics and Gynecology, Aalborg University HospitalDepartment of Obstetrics and Gynecology, Copenhagen University Hospital - Holb?k||Department of Clinical Medicine, University of CopenhagenDepartment of Obstetrics and Gynecology, Copenhagen University Hospital ¨C Herlev and GentofteDepartment of Obstetrics and Gynecology, Horsens Regional HospitalDepartment of Obstetrics and Gynecology, Copenhagen University Hospital - RigshospitaletDepartment of Obstetrics and Gynecology, Odense University HospitalDepartment of Obstetrics and Gynecology, Randers Regional HospitalDepartment of Obstetrics and Gynecology, Aarhus University Hospital
妇产科学医学研究方法医学现状、医学发展
Severe acute respiratory syndrome coronavirus 2COVID-19Obstetric deliveryPregnancy complicationsPregnancy outcomeCohort studiesProspective studies
Rubin Katrine H,Br¨1lle Anne-Line,Rathcke Sidsel L,Petersen Lone K,Bliddal Mette,Petersen Tanja G,Corn Giulia,Jonsdottir Fjola,Andersen Charlotte S,Sundtoft Iben,Milbak Julie,Khalil Mohammed R,Henriksen Birgitte,Andersen Lise LT,Vestgaard Marianne,Krebs Lone,J?nsson Lisbeth,Thorsen-Meyer Annette,Stokholm Lonny,Andersen Line S,Tatla Manrinder K,J?rgensen Jan S,Clausen Tine,Kjeldsen Frank S,Hansen Lea,Farlie Richard,Burmester Lars,Gulbech Arense,Thisted Dorthe,Ibsen Mette H,W?jdemann Karen,Andersson Charlotte B,S?rensen Anne N,Aabakke Anna JM,R?nneberg Elisabeth,Lindved Birgitte,Klemmensen ?se,Karlsen Kamilla K,Pedersen Monica L,Hvidman Lone.SARS-CoV-2 infection in pregnancy in Denmark – characteristics and outcomes after confirmed infection in pregnancy: a nationwide, prospective, population-based cohort study[EB/OL].(2025-03-28)[2025-05-13].https://www.medrxiv.org/content/10.1101/2021.06.08.21258480.点此复制
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