胶原海绵的酶降解行为研究
In vitro study on the degradation behavior of collagen by collagenase
胶原蛋白是由成纤维细胞合成的一种重要的蛋白，是最重要的细胞外间质成分，广泛应用于生物医学材料领域。本文采用不同比例的胶原蛋白与壳聚糖进行交联，以含胶原酶的PBS为降解液，以羟脯氨酸作为监测指标，考察各不同交联程度的胶原的降解行为，探求胶原的体外降解特性与交联作用的关系。
ollagen protein, which has been extensively used as biomaterial, is an important protein derived by fibroblasts and the most important component of extracellular matrix. In order to investigate the effect of cross-link upon its degradation behavior by collagenase in vitro, the experiment was carried out by cross-linking different concentration collagen solution with chitosan in different ratio respectively and PBS with collagenase as degradation solution, as well as hydroxyproline as the indicator.
李校堃、刘彬、麻开旺、蔡绍皙、王为
生物科学研究方法、生物科学研究技术基础医学生物化学
胶原蛋白 胶原 降解
collagen protein collagen degradation behavior
李校堃,刘彬,麻开旺,蔡绍皙,王为.胶原海绵的酶降解行为研究[EB/OL].(2006-07-27)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/200607-297.点此复制
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