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“忽冷忽热”的杏仁核:与攻击相关的重要核团

中文摘要英文摘要

攻击是有意对他人造成直接伤害的行为,可以分为反应性攻击和主动性攻击。攻击行为的发生有其神经生理基础,作为情绪加工和学习的关键脑区,杏仁核与攻击有着密切的关联。战斗-逃跑机制模型、暴力抑制机制模型和恐惧功能障碍假说强调了杏仁核对于攻击的重要性。表现出攻击或暴力行为的群体存在杏仁核的结构缺陷和功能障碍,其中功能障碍有两种相反的异常表现:在具有反应性攻击表现的高危人群中,杏仁核对威胁性刺激的反应增强(“热”反应);而以主动性攻击为主的人群如带有冷酷无情特质的精神病态人群,会表现出对威胁性刺激以及他人痛苦情绪线索的杏仁核反应减弱,以及在恐惧条件学习和道德决策的过程中杏仁核的激活不足的现象(“冷”反应)。这些功能障碍损害了个体在威胁反应、共情能力、惩罚回避以及道德决策等方面的正常水平。未来研究需人群研究和过程研究并举,关注杏仁核子结构的功能,探究攻击的神经网络基础,并探索有效的暴力防治干预手段。

ggression is the act of intentionally causing direct harm to others, and can be divided into reactive aggression and proactive aggression. The occurrence of aggression has neurobiological basis. As a key brain area of emotion processing and learning, the amygdala is closely associated with aggression. The fight-flight mechanism model, the violence inhibition mechanism model and the fear dysfunction hypothesis emphasize the importance of the amygdala for aggression. Groups exhibiting aggressive or violent behaviors have structural deficits and dysfunctions in the amygdala, in which dysfunction manifests itself with two opposite abnormalities. In high-risk groups with reactive aggression, the amygdala has an enhanced response to threatening stimuli ('hot' response); whereas groups with proactive aggression, such as psychopathic individuals with callous-unemotional traits, exhibit diminished amygdala responses to threatening stimuli and others distress cues, as well as in sufficient activation of the amygdala during fear conditioning learning and moral decision-making ('cold' response). These dysfunctions impair the individuals normal levels of threat response, empathy, punishment avoidance and moral decision-making. Future research needs to focus on both population research and process research, pay more attention to the functions of the substructures of the amygdala, explore the neural network foundations of aggression, and explore effective means of violence prevention and intervention.

杨波、赵辉、张亚冉、张卓、肖玉琴

10.12074/202303.08256V1

神经病学、精神病学基础医学生理学

杏仁核反应性攻击主动性攻击精神病态

杨波,赵辉,张亚冉,张卓,肖玉琴.“忽冷忽热”的杏仁核:与攻击相关的重要核团[EB/OL].(2023-03-20)[2025-08-11].https://chinaxiv.org/abs/202303.08256.点此复制

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