PTENp1、PTEN及miR-21在口腔鳞状细胞癌中的表达及其临床意义

Purpose：To evaluate the clinical significance of PTENp1,PTEN and miR-21 in oral squamous cell carcinomas. Methods: The 44 cases tissue specimens and paracancerous tissues were collected during January 1992 to January 2007, qRT-PCR was used to detect the expression levels and correlation of PTENp1,PTEN and miR-21 expression in those specimens. Results: qRT-PCR showed that the levels of PTEN and PTENp1 expression were significantly decreased in OSCC tissues compared with normal tissues (P＜0.05), while the expression of miR-21 was upregulated in OSCC tissues compared with normal tissues (P＜0.05). Furthermore, Pearson analysis demonstrated that no siginificant correlation between PTEN and miR-21 was observed in OSCC tissues（R = 0.032，P = 0.6603）, while the expression of PTEN positively correlated with the expression of PTENp1（R = 0.1970，P = 0.007）. Conclusion: Our ?ndings suggest that PTENp1, as the ceRNA of PTEN, competitively bind the miR-21 to regulate the biological behaviour of OSCC.