神经生长导向因子Semaphorin3家族在肿瘤中表达的系统分析

lass 3 Semaphorin(Sema3) is a secreted semaphorin subfamily which functions as guidance cues of axonal growth cone during the development of the nerve system. Sema3 also controls angiogenesis in normal and pathological settings and affect tumor cell proliferation, migration and adhesion in cell culture or tumor progression of the xenografts. In this article, the author used Fluorescence quantitative PCR and analysed the expression pattern in 28 tumor cell lines. The functional analysis of neural guidance molecules in cancer should consider the origin and the type of the tumor. Our result built a good foundation for future study.