炎性因子在癫痫发生发展中的作用

Epilepsy is a common,serious neurologic disorder characterized by recurring unprovoked seizures that result from abnormal firing of populations of neurons in the brain.As a crucial component of brain innate immunity, neuroinflammation initially contributes to neuronal tissue repair and maintenance. However, chronic inflammatory processes within the brain and associated blood-brain barrier (BBB) impairment often cause neurotoxicity and hyperexcitability.Mounting evidence points to a mutual facilitation between inflammation and epilepsy, suggesting that blocking the undesired inflammatory signaling within the brain might provide novel strategies to treat seizures and epilepsy. The change of inflammatory factors in the brain is one of the important changes in the occurrence and development of epilepsy. In this paper, we reviewed the relationship between epilepsy and inflammatory response, and some of the major inflammatory factors involved in the development of epilepsy.