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病毒相关性肝细胞癌的抗病毒疗法研究进展

he research progress of antiviral therapy of virus-related hepatocellular carcinoma

中文摘要英文摘要

随着医疗技术的进步,肝癌的治疗已有了长足的发展,患者的总体生存期和无瘤生存期明显延长。但是即使在经过手术切除和消融治疗等可治愈疗法后肝癌的复发率仍然很高。目前认为慢性HBV、HCV感染与肝癌的复发有密切关系,可能参与第二次致癌过程。所以,在经过可手术切除等可治愈疗法后进行抗病毒治疗在预防和延迟复发及提高病毒相关型肝癌患者的生存率具有重要意义。同时病毒感染与肝癌细胞对抗癌药物的耐药性有一定的联系,可能会在一定的程度上降低抗癌药物的疗效,因此,抗病毒治疗在增强抗癌药物的效能方面也能发挥重要作用。本文就对病毒诱发型肝癌发病机制、肝癌治疗中抗病毒治疗重要性及抗病毒疗法的应用进展进行综述。

With the development of medical technology,,the remarkable advances have been made in the therapy of hepatocellular carcinoma,The overall survival and disease-free survival of patients has been significantly prolonged.However,The recurrence rate is still high after a potentially curative treatment such as surgical interference or locoregional ablative therapie. At present, Chronic HBV/HCV infection is thought to be related with the recurrence of tumor and may take part in the process of secondary carcinogenesis.So,antiviral therapy has important implications for preventing and delaying relapse and improving the survival rate of patients with chronic virus infection after after a potentially curative treatment such as surgical interference.At the same time,virus infection has some relationship with drug resistance for the anticarcinogen ,as a result,it can reduce the effectiveness of anti-cancer drugs to some extent.therefore,antiviral therapy may play an important role in improving the effectiveness of anticarcinogen. In this article,the pathogenesis of virus -related hepatocellular carcinoma,the importance of antiviral therapy in the management of hepatocellular carcinoma and application progress of antiviral therapy were summarized

陈志刚、邬国斌、黄超源

肿瘤学医药卫生理论基础医学

原发性肝细胞癌抗病毒疗法HBV/HCV

primary hepatocellular carcinomantiviral therapyHBV/HCV

陈志刚,邬国斌,黄超源.病毒相关性肝细胞癌的抗病毒疗法研究进展[EB/OL].(2013-10-24)[2025-04-29].http://www.paper.edu.cn/releasepaper/content/201310-321.点此复制

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