Krupel样转录因子家族在免疫细胞中的作用

Kruppel-like transcription factors (KLF) family is a subgroup in the Zinc finger protein super family. To date, there are 17 members of the mammalian KLF family. The KLF family participates in diverse aspects of cellular growth, development, activation, differentiation and apoptosis. Nowadays more and more studies indicated that Kruppel-like factors (KLFs) may be key transacting factors that involved in leukocyte biology, including migration of T cells, differentiation and function of regulatory T cells, activation or renewal of mononuclear-macrophage, and maturation or activation of B cells. In this article, we reviewed the structural features of KLF family and especially the function of several KLFs that involved in leukocyte biology.