DPP6 gene in European American Alzheimer’s Disease
DPP6 gene in European American Alzheimer’s Disease
Abstract DPP6 encodes a transmembrane protein that expresses highly in the hippocampal regions of the brain and regulates dendritic excitability. Recently, rare and loss of function variants were reported in DPP6 and further demonstrated to be associated with early onset Alzheimer Disease (AD) and frontotemporal dementia. We performed single variant and gene-based analyses in three non-Hispanic white cohorts: a familial late onset AD (cases=1212, controls=341), an unrelated early onset AD (cases=1385, controls=3864) and in the unrelated Alzheimer disease sequencing project (ADSP, cases=5679, controls=4601). Neither single variant or gene-based analysis revealed any significant statistical association of DPP6 variants with the risk for AD in the cohorts examined.
NIA-LOAD family study group, NCRAD, the ADSP project、Budde John P.、Kirola Laxmi、Fern¨￠ndez Maria Victoria、Norton Joanne、Cruchaga Carlos、Wang Fengxian、Morris John C.
Dept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSM||NeuroGenomics and Informatics Center, Washington University School of MedicineDept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSMDept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSM||NeuroGenomics and Informatics Center, Washington University School of MedicineDept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSM||NeuroGenomics and Informatics Center, Washington University School of MedicineDept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSM||NeuroGenomics and Informatics Center, Washington University School of MedicineDept Psychiatry, Washington University School of Medicine (WUSM)||Hope Center for Neurological Disorders. WUSM||NeuroGenomics and Informatics Center, Washington University School of MedicineHope Center for Neurological Disorders. WUSM||Knight Alzheimer Disease Research Center
神经病学、精神病学基础医学分子生物学
Alzheimer’s diseasewhole exome sequencingwhole genome sequencingDPP6gene burden analysis
NIA-LOAD family study group, NCRAD, the ADSP project,Budde John P.,Kirola Laxmi,Fern¨￠ndez Maria Victoria,Norton Joanne,Cruchaga Carlos,Wang Fengxian,Morris John C..DPP6 gene in European American Alzheimer’s Disease[EB/OL].(2025-03-28)[2025-05-03].https://www.medrxiv.org/content/10.1101/2020.10.23.20216408.点此复制
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