5-羟色胺2C受体基因多态性与甘肃东乡族2型糖尿病的关系

o study the association of the -759C/T polymorphism of the 5-hydroxytryptamine 2C(5-HT2C) receptor gene with type 2 diabetes and obesity in Gansu DongXiang nationality. The 5-HT2C receptor gene -759C/T polymorphism was detected by PCR-ligase detection reaction(PCR-LDR) technique in 100 type 2 diabetics and 126 normal control subjects. The clinical parameters and serum markers were also measured. 1) The frequency of CC,CT genotypes in female diabetics and normal control subjects were 80.6%,19.4% and 61%,39% respectively. The frequency of CT genotype was significantly lower in the female diabetics than in the normal control subjects(P ＜0.05),and the allele frequencies showed no statistical difference between two groups(P ＞0.05). The frequency of C and T hemizygote also showed no statistical difference between male diabetics and normal control subjects(P ＞0.05).2) The genotype and allele frequencies of -759C/T were not significantly different between female obese group and nonobese group(P＞0.05). The frequency of C and T hemizygote showed no significantly difference between male obese group and nonobese group(P＞0.05).The 5-HT2C receptor gene -759C/T polymorphism is associated with type 2 diabetes in female DongXiang nationality. -759C→T may be a protective factor for the development of T2DM.