叶酸、维生素B12、普罗布考与原发性高血压干预治疗的研究

Objective To investigate the internal relationship among ADMA、Hcy after the supplementation of folic acid、vitamin B12 and probucol to explore mechanism of hypertension and preventive measures. Method A total of 120 patients with hypertension were randomly divided into three groups. Among the first group we gave only anti-hypertensive treatment, and the second group on the basis of treatment of the first group were given folic acid and VitB12. The third group on the basis of treatment of the second group were given probucol. Additionally，30 healthy people were selected as control group. Observe changes of ADMA、Hcy among the baseline、2 weeks and 12 weeks. Results Plasma ADMA、Hcy concentration in patients with essential hypertension were both significantly higher than the concentration of control group (P<0.01)；In the first group concentrations of plasma ADMA、Hcy had not significantly differences(P>0.05);In the second group plasma ADMA、Hcy concentrations after treatment of 12 weeks had more significantly differences than the baseline and treatment of 2 weeks (P<0.01)；In the third group plasma ADMA、Hcy concentrations after treatment of 2 weeks had more significantly differences than the baseline (P<0.01), after treatment of 12 weeks they had more significantly differences than the baseline and treatment of 2 weeks (P<0.01). Plasma levels of ADMA were positively correlated with Hcy (P<0.05). Conclusions The supplementation of folic acid、VitB12 and/or probucol may help improve endothelial function and inhibit the vicious circle by the reduction of ADMA and Hcy，slowing the progress of atherosclerosis and preventing cardiovascular events in patients with hypertension．