社区老年人认知功能受损与睡眠时间的关联研究
he association of cognitive impairment with sleep duration among community?dwelling older adults
目的 探讨社区老年人认知功能受损与夜间睡眠时间的关联。方法 2018年7月～9月，从安徽省阜阳市8个区、县随机抽取60岁及以上社区老年人6000人，纳入分析4837人。一般人口学特征（性别、年龄、地区、文化程度等）、生活习惯、慢性病史、睡眠时间和总体认知功能通过问卷进行调查。logistic回归被用于探讨夜间睡眠时间与认知功能受损的关联。限制性立方样条模型被用于绘制睡眠时间与认知功能受损的剂量-反应曲线。结果 在未调整的回归结果中，与正常睡眠时间（6~8h）组相比，睡眠时间较短（≤6h）组和睡眠时间较长（＞8h）组老年人发生认知功能受损的比值比分别为1.25（95%CI: 1.09~1.42）和1.41（95%CI:1.21~1.65）。进一步对混杂因素进行调整的结果表明，相比于正常睡眠时间组，睡眠时间较短组和睡眠时间较长组老年人发生认知功能受损的风险分别增加26%（OR=1.26, 95%CI: 1.09~1.46）和22%（OR=1.22，95%CI: 1.03~1.46）。基于性别分层，睡眠时间较长与认知功能受损的关联在男性老人中更显著，睡眠时间较短与认知功能受损的关联则在女性老人中更显著。限制性立方样条曲线显示睡眠时间与认知功能受损发生风险呈近似“U”形关系，低点在7h左右。结论 睡眠时间较短或较长可能是认知功能受损的独立、剂量依赖性的关联因素；最佳的睡眠时间在7h左右；男性睡眠时间较长与认知功能受损的关联强度高于女性，女性睡眠时间较短与认知功能受损的关联强度高于男性。因此，应对老年人的睡眠时间进行指导，以缓解老年群体认知功能受损的发生风险。
ObjectiveTo examine the association between cognitive impairment and sleep duration among community-dwelling older adults. MethodsFrom July to September 2018, a total of 6000 communitydwelling older adults aged 60 years or over from 8 districts and counties of Fuyang city in Anhui province were selected to participate in this study, and 4837 older adults were included in the final analyses. Demographicscharacteristics(gender, age, region, education, etc.), living habits, chronic diseases, sleep duration, and globalcognitivefunction were assessed. Logistic regression models and restricted cubic spline (RCS) models were applied to examine the association between sleep duration and cognitive impairment for the total sample and by gender. ResultsIn unadjusted logistic regression models, both short sleep duration (6h) (OR=1.25, 95%CI: 1.09-1.42) and long sleep duration (8 h) (OR=1.41, 95%CI: 1.21-1.65) had higher odds of cognitive impairment as compared with normal sleep duration (6-8h). The further adjustment for confounding factors showed that both short sleep duration (OR=1.26, 95%CI:1.09-1.46) and long sleep duration (OR=1.22, 95%CI: 1.03-1.46) had higher odds of cognitive impairment as compared with normal sleep duration. Stratified analysis showed that the association between longer sleep and impaired cognitive function was stronger in older men than in women, while shorter sleep was stronger in older women than in men. An approximately U-shaped relationship was detected between sleep duration and the risk of cognitive impairment, with a low point of 7 hours. ConclusionsBoth short and long sleep duration are independent and dose-dependent associated factors with cognitive impairment among community-dwelling older adults. The best sleep duration is about 7h and the association between longer sleep duration and impaired cognitive function was stronger in men than in women, and shorter sleep duration was stronger in women than in men. Therefore, it is necessary to guide sleep duration of older adults, so as to reduce the risk of cognitive impairment.
聂欢欢, 杨林胜
10.12114/j.issn.1007-9572.2022.0766
神经病学、精神病学预防医学
认知功能受损睡眠时间老年人
聂欢欢, 杨林胜.社区老年人认知功能受损与睡眠时间的关联研究[EB/OL].(2022-11-14)[2025-05-15].https://chinaxiv.org/abs/202211.00154.点此复制
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